Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Beta-caryophyllene (BCP) is a natural bicyclic sesquiterpene present in essential oils of numerous plants, including black pepper, clove, and cannabis. There is emerging scientific evidence to support its potential role in alleviating anxiety disorders, primarily based on preclinical studies. BCP acts as a selective agonist of the cannabinoid receptor type 2 (CB2), which is part of the endocannabinoid system involved in regulating mood, inflammation, and stress responses.

Several animal studies have demonstrated that BCP can produce anxiolytic-like effects. For example, a study published in "Physiology & Behavior" (2014) found that BCP significantly reduced anxiety-like behaviors in mice subjected to chronic stress. Another study in "Phytotherapy Research" (2016) indicated BCP’s anxiolytic and antidepressant effects are mediated through CB2 receptor activation. Importantly, BCP does not bind to CB1 receptors, thus it does not produce psychoactive effects typical of THC.

However, human clinical trials are lacking, and most of the evidence comes from animal models or in vitro studies. While the preclinical data is promising and suggests a plausible mechanism of action, the translation of these findings to human anxiety disorders remains to be established. Therefore, while BCP is scientifically investigated for anxiety, the current level of evidence is still preliminary.

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