Evidence supporting the use of: Bifidobacterium longum
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bifidobacterium longum is a probiotic bacterium that has garnered scientific interest for its potential effects on mental health, including anxiety disorders. The rationale for its use is based on the concept of the "gut-brain axis," which describes the bidirectional communication between the gastrointestinal tract and the central nervous system. Animal studies have shown that B. longum can modulate behavior under stress, reduce anxiety-like symptoms, and influence neurotransmitter levels. For example, a 2011 study (Savignac et al., Neuroscience) demonstrated that B. longum reduced anxiety-like behavior in mice. In humans, a small number of clinical trials provide preliminary support: a randomized, double-blind, placebo-controlled trial (Allen et al., Neurogastroenterology & Motility, 2016) found that a combination of B. longum 1714 and other probiotics reduced subjective measures of stress and improved memory in healthy volunteers. Another study (Tillisch et al., Gastroenterology, 2013) showed that probiotic intake altered brain activity in areas involved in emotion and sensation.

However, evidence remains limited, with most studies being small, short-term, and sometimes using multi-strain formulations, making it difficult to ascribe the effects solely to B. longum. Systematic reviews (e.g., Liu et al., General Psychiatry, 2019) conclude that while probiotics may benefit mood and anxiety, larger and more rigorous human studies are needed. Thus, the evidence is promising but not yet robust, meriting a moderate evidence rating.

More about bifidobacterium longum
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Other ingredients used for Anxiety Disorders

5-Hydroxytryptophan (5-HTP)
amino acids
ashwagandha
waterhyssop
beta caryophyllene
bifidobacterium infantis
bifidobacterium longum
cannabis sativa oil
chamomile
citrus oil
curcumin
ginkgo biloba
ginseng
gotu kola
green tea
hemp oil
inositol
kava
L-glycine
L-taurine
L-theanine
L-tryptophan
lactium casein decapeptide
lactobacillus casei
lactobacillus paracasei
lactobacillus rhamnosus
lavender
lion's mane
lithium orotate
magnesium
magnolia
matcha
melatonin
motherwort
muira puama
n-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
phosphatidylserine
phytocannabinoids
polygala root
prebiotic blend (proprietary)
pregnenolone
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
rhodiola
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sceletium
skullcap
valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
zinc
catnip
shen-chu
St. John's Wort
herbal blend (proprietary)
cocoa
star of Bethlehem
7,8-Dihydroxyflavone
Apigenin
Albizia
Aconite
Baikal Skullcap
Bifidobacterium adolescentis
Bacopin
Brahmi
Bacopa
bacoside
Clary sage
Cymbopogon Martini
Centella asiatica
Capitate Valerian
Cowslip
Cannabidiol
Convolvulus prostratus
Convolvulus Pluricaulis
Essential Oil Blend
Gelsemium
Griffonia simplicifolia
Ginkgoside
Gastrodin
Honokiol
Hypericum
hyperforin
Hericium mushroom
Hemp
Jujubosides
Kavalactones
Kefir
lemon balm
Linden
Lactococcus rhamnosus
Lavandin
Large-Leaved Linden
Lactobacillus
Linalool
Mimulus
Monoterpenes
Magnolol
Mulungu
Mesembrine
Pulsatilla
Probiotics
Passionfruit
Polygala
Purple Monkeyflower
Rosavins
Rosmarinic Acid
Spikenard
Scleranthus annus
Shankhpushpi
Sandalwood
Saffranal
Terpenoids
Tea
Trichilia catigua
Tetrahydropalmatine
Valerenic acid
Vervain
Vitexin
Wogonin
yohimbine