Evidence supporting the use of: Cannabidiol
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Cannabidiol (CBD) has garnered significant interest as a potential treatment for anxiety disorders. Several preclinical studies using animal models have suggested that CBD exerts anxiolytic (anxiety-reducing) effects, possibly by interacting with serotonin (5-HT1A) receptors and modulating the endocannabinoid system. In humans, a handful of small randomized controlled trials (RCTs) and experimental studies have provided preliminary evidence supporting CBD’s anxiolytic properties. For example, a 2011 study published in Neuropsychopharmacology found that acute administration of CBD (600 mg) reduced anxiety in subjects with social anxiety disorder during a simulated public speaking test. Additional small trials and case series have reported improvements in anxiety symptoms among patients with generalized anxiety disorder, social anxiety disorder, and post-traumatic stress disorder (PTSD).

However, the overall quality of evidence is limited by small sample sizes, short durations, heterogeneity of dosing, and lack of standardization in CBD preparations. Systematic reviews and meta-analyses (such as Blessing et al., 2015, and Skelley et al., 2020) conclude that while early findings are promising, robust clinical trials are needed to confirm efficacy, determine optimal dosing, and assess long-term safety. Currently, CBD is not an FDA-approved treatment for anxiety disorders. In summary, there is emerging but not definitive scientific evidence supporting the use of cannabidiol for anxiety disorders.

More about cannabidiol
More about Anxiety Disorders

Other ingredients used for Anxiety Disorders

5-Hydroxytryptophan (5-HTP)
7,8-Dihydroxyflavone
Aconite
Albizia
amino acids
apigenin
ashwagandha
Bacopa
Bacopin
bacoside
Baikal Skullcap
beta caryophyllene
Bifidobacterium adolescentis
Bifidobacterium infantis
Bifidobacterium longum
brahmi
cannabidiol
Cannabis sativa oil
Capitate Valerian
catnip
Centella asiatica
chamomile
Clary sage
cocoa
Convolvulus pluricaulis
Convolvulus prostratus
cowslip
curcumin
Cymbopogon martini
essential oil blend
gastrodin
Gelsemium
ginkgo biloba
Ginkgoside
ginseng
gotu kola
green tea
Griffonia simplicifolia
hemp
hemp oil
herbal blend (proprietary)
hericium mushroom
Honokiol
hyperforin
Hypericum
inositol
jujubosides
kava
kavalactones
Kefir
L-glycine
L-taurine
L-theanine
L-tryptophan
lactium casein decapeptide
Lactobacillus
Lactobacillus casei
Lactobacillus paracasei
Lactobacillus rhamnosus
Lactococcus rhamnosus
Large-leaved linden
Lavandin
lavender
lemon balm
linalool
linden
lion's mane
lithium orotate
magnesium
magnolia
magnolol
Matcha
Melatonin
Mesembrine
Mimulus
Monoterpenes
Motherwort
Muira puama
Mulungu
N-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
Passionfruit
phosphatidylserine
phytocannabinoids
Polygala
polygala root
prebiotic blend (proprietary)
pregnenolone
probiotics
Pulsatilla
Purple Monkeyflower
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
Rhodiola
rosavins
rosmarinic acid
Safranal
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Sandalwood
sceletium
Scleranthus annus
Shankhpushpi
shen-chu
skullcap
Spikenard
St. John's Wort
star of Bethlehem
Tea
Terpenoids
Tetrahydropalmatine
Trichilia catigua
Valerenic acid
Valerian root
velvet bean
Vervain
vitamin B
vitamin B12
vitamin B6
Vitexin
Waterhyssop
Wogonin
Yohimbine
Zinc

Products containing cannabidiol

We currently have no products on Vitabase that contain this ingredient.