Evidence supporting the use of: Cannabis
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cannabis and its constituents, particularly cannabidiol (CBD), have been investigated for their potential to support or treat anxiety disorders. The scientific evidence is mixed and primarily comes from small-scale human studies, animal research, and anecdotal reports. Some clinical trials indicate that CBD, a non-intoxicating component of cannabis, may reduce anxiety in specific contexts, such as public speaking or in patients with social anxiety disorder. For example, a well-known 2011 study published in "Neuropsychopharmacology" found that CBD reduced anxiety in subjects with social anxiety disorder during a simulated public speaking test. Animal studies have also shown anxiolytic (anxiety-reducing) effects of CBD. However, the evidence for tetrahydrocannabinol (THC), the psychoactive component of cannabis, is less clear and may even suggest anxiogenic (anxiety-increasing) effects at higher doses. There is also a risk of paradoxical reactions, with some users reporting increased anxiety or panic attacks, especially at higher doses or with high-THC strains. Systematic reviews and meta-analyses highlight the need for larger, better-designed randomized controlled trials. Current guidelines do not universally recommend cannabis or cannabinoids for anxiety disorders due to the lack of robust evidence, variability in individual response, and potential risks. In summary, while there is some scientific interest and preliminary support for certain cannabinoids (notably CBD), the overall evidence is still limited and warrants caution.

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