Evidence supporting the use of: Flavanoid (mixture)
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavonoids are a diverse group of plant-derived polyphenolic compounds found in foods such as fruits, vegetables, tea, and wine. There is emerging scientific evidence suggesting that certain flavonoids may exert anxiolytic (anxiety-reducing) effects, primarily through modulation of neurotransmitter systems, antioxidant activity, and anti-inflammatory effects. Preclinical studies, particularly in rodent models, have demonstrated that flavonoids such as quercetin, apigenin, luteolin, and kaempferol can reduce anxiety-like behaviors. Mechanistic studies indicate that these effects may be mediated via the GABAergic system, serotonergic modulation, and reduction of oxidative stress. A small number of early-phase clinical trials have explored the impact of flavonoid-rich extracts (e.g., from passionflower or chamomile) on anxiety symptoms in humans, showing some promise but with mixed results. However, these studies often use extracts containing multiple bioactive ingredients, making it difficult to attribute effects specifically to flavonoids. There is currently insufficient high-quality, large-scale clinical evidence to support the widespread use of flavonoid mixtures as anxiolytic agents in humans. Overall, while the mechanistic basis and animal data are encouraging, clinical validation remains limited, and more rigorous trials are needed to fully establish efficacy and safety.

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