Evidence supporting the use of: Ginkgo biloba
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ginkgo biloba has been investigated for its potential to alleviate symptoms of anxiety disorders, though the scientific evidence is limited and not conclusive. Several small-scale clinical studies have explored Ginkgo's anxiolytic (anxiety-reducing) effects. For example, a 2007 randomized, double-blind, placebo-controlled study published in Journal of Psychiatric Research found that participants with generalized anxiety disorder or adjustment disorder with anxious mood who received a standardized Ginkgo extract (EGb 761) experienced a greater reduction in anxiety symptoms compared to placebo. The proposed mechanisms include Ginkgo’s antioxidant properties, modulation of neurotransmitter systems (such as serotonin and dopamine), and improvement of cerebral blood flow, all of which may influence mood and anxiety levels.

Despite these findings, the body of research is relatively small, studies have methodological limitations (such as small sample sizes and short durations), and results are inconsistent. Major clinical guidelines do not currently recommend Ginkgo biloba as a first-line or evidence-based treatment for anxiety disorders. Its use is more often as a complementary or alternative therapy, sometimes chosen by individuals seeking "natural" options. Overall, while there is preliminary scientific support suggesting Ginkgo biloba may help with anxiety symptoms, the evidence is not robust. Larger, high-quality studies are needed to establish efficacy and safety for this indication.

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