Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Griffonia simplicifolia is a West African plant whose seeds are a natural source of 5-hydroxytryptophan (5-HTP), a direct precursor to serotonin. Serotonin is a neurotransmitter involved in mood regulation, and low serotonin levels are associated with anxiety disorders. The rationale for using Griffonia simplicifolia in anxiety is thus based on increasing brain serotonin levels via 5-HTP supplementation. Several small-scale human and animal studies suggest that 5-HTP supplementation may have anxiolytic (anxiety-reducing) effects. For example, some clinical trials have shown that 5-HTP can reduce symptoms in people with anxiety or panic disorders, but the number of well-designed, large randomized controlled trials (RCTs) is limited. Most available studies are either small, short-term, or focus on depressive symptoms rather than anxiety specifically. Systematic reviews generally conclude that while there is biological plausibility and preliminary evidence, the clinical evidence is insufficient to strongly recommend 5-HTP (or Griffonia simplicifolia) for anxiety disorders. Safety is another consideration, as 5-HTP can cause side effects and interact with medications. In summary, while there is a scientific basis and some early evidence for the use of Griffonia simplicifolia in anxiety disorders, the overall quality and quantity of evidence is low, justifying a moderate-low evidence rating.

More about Griffonia simplicifolia
More about Anxiety Disorders

Other ingredients used for Anxiety Disorders

5-Hydroxytryptophan (5-HTP)
7,8-Dihydroxyflavone
Aconite
Albizia
amino acids
apigenin
ashwagandha
Bacopa
Bacopin
bacoside
Baikal Skullcap
beta caryophyllene
Bifidobacterium adolescentis
Bifidobacterium infantis
Bifidobacterium longum
brahmi
cannabidiol
Cannabis sativa oil
Capitate Valerian
catnip
Centella asiatica
chamomile
Clary sage
cocoa
Convolvulus pluricaulis
Convolvulus prostratus
cowslip
curcumin
Cymbopogon martini
essential oil blend
gastrodin
Gelsemium
ginkgo biloba
Ginkgoside
ginseng
gotu kola
green tea
Griffonia simplicifolia
hemp
hemp oil
herbal blend (proprietary)
hericium mushroom
Honokiol
hyperforin
Hypericum
inositol
jujubosides
kava
kavalactones
Kefir
L-glycine
L-taurine
L-theanine
L-tryptophan
lactium casein decapeptide
Lactobacillus
Lactobacillus casei
Lactobacillus paracasei
Lactobacillus rhamnosus
Lactococcus rhamnosus
Large-leaved linden
Lavandin
lavender
lemon balm
linalool
linden
lion's mane
lithium orotate
magnesium
magnolia
magnolol
Matcha
Melatonin
Mesembrine
Mimulus
Monoterpenes
Motherwort
Muira puama
Mulungu
N-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
Passionfruit
phosphatidylserine
phytocannabinoids
Polygala
polygala root
prebiotic blend (proprietary)
pregnenolone
probiotics
Pulsatilla
Purple Monkeyflower
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
Rhodiola
rosavins
rosmarinic acid
Safranal
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Sandalwood
sceletium
Scleranthus annus
Shankhpushpi
shen-chu
skullcap
Spikenard
St. John's Wort
star of Bethlehem
Tea
Terpenoids
Tetrahydropalmatine
Trichilia catigua
Valerenic acid
Valerian root
velvet bean
Vervain
vitamin B
vitamin B12
vitamin B6
Vitexin
Waterhyssop
Wogonin
Yohimbine
Zinc

Other health conditions supported by Griffonia simplicifolia

Anxiety
Anxiety Disorders
Depression
Sleep (restless and disturbed)
Stress

Products containing Griffonia simplicifolia

We currently have no products on Vitabase that contain this ingredient.