Evidence supporting the use of: Hericium mushroom
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hericium mushroom (commonly known as Lion's Mane, Hericium erinaceus) has been investigated in several preclinical and limited clinical studies for its potential effects on mental health, including anxiety disorders. Scientific interest in Lion's Mane is due to its content of bioactive compounds such as hericenones and erinacines, which may stimulate nerve growth factor (NGF) synthesis and modulate neuroinflammation.

A small number of human studies have explored Lion's Mane's anxiolytic properties. Notably, a double-blind, placebo-controlled pilot study in 2010 (Nagano et al.) involving menopausal women reported reduced scores for anxiety and irritability after four weeks of Lion's Mane supplementation. Animal studies have also shown decreased anxiety-like behaviors in rodents, possibly linked to neuroprotective and anti-inflammatory mechanisms.

However, the current body of evidence is limited by small sample sizes, short durations, and a lack of studies specifically targeting clinical anxiety disorders. Most research to date is preliminary, and there is insufficient high-quality clinical data to firmly establish Lion's Mane as an effective treatment for anxiety disorders.

In summary, while there is scientific interest and some early evidence suggesting a potential anxiolytic effect of Hericium mushroom, the quality and quantity of evidence are currently low. Larger, well-designed clinical trials are needed to confirm efficacy and safety for anxiety disorders.

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