Evidence supporting the use of: Hyperforin
For the health condition: Anxiety Disorders
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Hyperforin is a major active constituent of Hypericum perforatum (St. John's Wort), a traditional herbal remedy with a long history of use for mood disorders. Its primary established use is in the treatment of mild to moderate depression. Some clinical and preclinical studies have explored its effects on anxiety, but the evidence is limited and less robust compared to its antidepressant properties. Hyperforin is believed to exert its effects by inhibiting the reuptake of several neurotransmitters, including serotonin, dopamine, norepinephrine, GABA, and glutamate, which may theoretically influence anxiety symptoms. However, randomized controlled trials (RCTs) specifically assessing hyperforin or St. John's Wort for anxiety disorders are sparse. A few small studies and meta-analyses suggest some potential anxiolytic effects, but methodological issues and inconsistent results limit definitive conclusions. Major clinical guidelines do not currently recommend hyperforin or St. John's Wort as a first-line treatment for anxiety disorders due to insufficient high-quality evidence. Overall, while there is some scientific rationale and preliminary clinical data, the evidence supporting the use of hyperforin for anxiety disorders is weak to moderate at best.
Other ingredients used for Anxiety Disorders
5-Hydroxytryptophan (5-HTP)7,8-Dihydroxyflavone
Aconite
Albizia
amino acids
apigenin
ashwagandha
Bacopa
Bacopin
bacoside
Baikal Skullcap
beta caryophyllene
Bifidobacterium adolescentis
Bifidobacterium infantis
Bifidobacterium longum
brahmi
cannabidiol
Cannabis sativa oil
Capitate Valerian
catnip
Centella asiatica
chamomile
Clary sage
cocoa
Convolvulus pluricaulis
Convolvulus prostratus
cowslip
curcumin
Cymbopogon martini
essential oil blend
gastrodin
Gelsemium
ginkgo biloba
Ginkgoside
ginseng
gotu kola
green tea
Griffonia simplicifolia
hemp
hemp oil
herbal blend (proprietary)
hericium mushroom
Honokiol
hyperforin
Hypericum
inositol
jujubosides
kava
kavalactones
Kefir
L-glycine
L-taurine
L-theanine
L-tryptophan
lactium casein decapeptide
Lactobacillus
Lactobacillus casei
Lactobacillus paracasei
Lactobacillus rhamnosus
Lactococcus rhamnosus
Large-leaved linden
Lavandin
lavender
lemon balm
linalool
linden
lion's mane
lithium orotate
magnesium
magnolia
magnolol
Matcha
Melatonin
Mesembrine
Mimulus
Monoterpenes
Motherwort
Muira puama
Mulungu
N-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
Passionfruit
phosphatidylserine
phytocannabinoids
Polygala
polygala root
prebiotic blend (proprietary)
pregnenolone
probiotics
Pulsatilla
Purple Monkeyflower
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
Rhodiola
rosavins
rosmarinic acid
Safranal
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Sandalwood
sceletium
Scleranthus annus
Shankhpushpi
shen-chu
skullcap
Spikenard
St. John's Wort
star of Bethlehem
Tea
Terpenoids
Tetrahydropalmatine
Trichilia catigua
Valerenic acid
Valerian root
velvet bean
Vervain
vitamin B
vitamin B12
vitamin B6
Vitexin
Waterhyssop
Wogonin
Yohimbine
Zinc