Evidence supporting the use of: Jujubosides
For the health condition: Anxiety Disorders
Synopsis
Source of validity: Traditional
Rating (out of 5): 2
Jujubosides are saponin compounds extracted from the seeds of Ziziphus jujuba (commonly known as jujube or suanzaoren in traditional Chinese medicine). The use of jujubosides to support or treat anxiety disorders is primarily based on longstanding traditional use rather than robust scientific validation. In traditional Chinese medicine, jujube seed extracts are employed as a sedative and anxiolytic, commonly found in formulas aimed at calming the mind and improving sleep. This historical use underpins the rationale for their use in anxiety-related conditions.
Some preclinical studies in rodents suggest that jujubosides may have anxiolytic and sedative effects, potentially through modulation of GABAergic neurotransmission and other central nervous system pathways. For example, animal studies have shown that jujubosides can reduce anxiety-like behavior and promote sleep in mice. However, these findings have not yet been substantiated by well-designed human clinical trials. There is a lack of high-quality, large-scale, randomized controlled trials examining the efficacy and safety of jujubosides for anxiety disorders in humans.
In summary, while jujubosides have a strong basis in traditional use for anxiety and related symptoms, scientific evidence supporting their effectiveness in humans is limited and preliminary. Therefore, their use is justified by tradition, with only modest support from animal studies and little confirmation in clinical research.
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5-Hydroxytryptophan (5-HTP)7,8-Dihydroxyflavone
Aconite
Albizia
amino acids
apigenin
ashwagandha
Bacopa
Bacopin
bacoside
Baikal Skullcap
beta caryophyllene
Bifidobacterium adolescentis
Bifidobacterium infantis
Bifidobacterium longum
brahmi
cannabidiol
Cannabis sativa oil
Capitate Valerian
catnip
Centella asiatica
chamomile
Clary sage
cocoa
Convolvulus pluricaulis
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cowslip
curcumin
Cymbopogon martini
essential oil blend
gastrodin
Gelsemium
ginkgo biloba
Ginkgoside
ginseng
gotu kola
green tea
Griffonia simplicifolia
hemp
hemp oil
herbal blend (proprietary)
hericium mushroom
Honokiol
hyperforin
Hypericum
inositol
jujubosides
kava
kavalactones
Kefir
L-glycine
L-taurine
L-theanine
L-tryptophan
lactium casein decapeptide
Lactobacillus
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Lactobacillus paracasei
Lactobacillus rhamnosus
Lactococcus rhamnosus
Large-leaved linden
Lavandin
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lemon balm
linalool
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lion's mane
lithium orotate
magnesium
magnolia
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Matcha
Melatonin
Mesembrine
Mimulus
Monoterpenes
Motherwort
Muira puama
Mulungu
N-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
Passionfruit
phosphatidylserine
phytocannabinoids
Polygala
polygala root
prebiotic blend (proprietary)
pregnenolone
probiotics
Pulsatilla
Purple Monkeyflower
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
Rhodiola
rosavins
rosmarinic acid
Safranal
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Sandalwood
sceletium
Scleranthus annus
Shankhpushpi
shen-chu
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Tea
Terpenoids
Tetrahydropalmatine
Trichilia catigua
Valerenic acid
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velvet bean
Vervain
vitamin B
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vitamin B6
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