Evidence supporting the use of: Lactobacillus rhamnosus
For the health condition: Anxiety Disorders

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus rhamnosus is a probiotic bacterium that has gained research interest for its potential effects on mental health, particularly anxiety disorders. The rationale behind its use is based on the concept of the "gut-brain axis"—a bidirectional communication pathway between the gastrointestinal tract and the central nervous system. Several preclinical studies in animal models have demonstrated that L. rhamnosus supplementation can influence behavior and neurochemistry associated with anxiety. Notably, a widely cited 2011 study by Bravo et al. found that mice given L. rhamnosus exhibited reduced anxiety- and depression-related behaviors, potentially through modulation of GABA receptor expression and vagus nerve signaling.

Human evidence, however, remains limited. A handful of small-scale clinical trials have explored the effects of L. rhamnosus on stress and mood, with some suggesting modest benefits but others showing no significant effects. Systematic reviews and meta-analyses generally conclude that while probiotics may have a positive impact on subjective stress and mood, the specific effects of L. rhamnosus on clinically diagnosed anxiety disorders in humans have not been conclusively demonstrated. The evidence quality is limited by small sample sizes, short study durations, and heterogeneity in study design.

In summary, while L. rhamnosus shows promise in preclinical models and is the subject of ongoing research, robust scientific validation in humans is currently lacking, resulting in a low-to-moderate evidence rating for its use in supporting or treating anxiety disorders.

More about Lactobacillus rhamnosus
More about Anxiety Disorders

Other ingredients used for Anxiety Disorders

5-Hydroxytryptophan (5-HTP)
7,8-Dihydroxyflavone
Aconite
Albizia
amino acids
apigenin
ashwagandha
Bacopa
Bacopin
bacoside
Baikal Skullcap
beta caryophyllene
Bifidobacterium adolescentis
Bifidobacterium infantis
Bifidobacterium longum
brahmi
cannabidiol
Cannabis sativa oil
Capitate Valerian
catnip
Centella asiatica
chamomile
Clary sage
cocoa
Convolvulus pluricaulis
Convolvulus prostratus
cowslip
curcumin
Cymbopogon martini
essential oil blend
gastrodin
Gelsemium
ginkgo biloba
Ginkgoside
ginseng
gotu kola
green tea
Griffonia simplicifolia
hemp
hemp oil
herbal blend (proprietary)
hericium mushroom
Honokiol
hyperforin
Hypericum
inositol
jujubosides
kava
kavalactones
Kefir
L-glycine
L-taurine
L-theanine
L-tryptophan
lactium casein decapeptide
Lactobacillus
Lactobacillus casei
Lactobacillus paracasei
Lactobacillus rhamnosus
Lactococcus rhamnosus
Large-leaved linden
Lavandin
lavender
lemon balm
linalool
linden
lion's mane
lithium orotate
magnesium
magnolia
magnolol
Matcha
Melatonin
Mesembrine
Mimulus
Monoterpenes
Motherwort
Muira puama
Mulungu
N-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
Passionfruit
phosphatidylserine
phytocannabinoids
Polygala
polygala root
prebiotic blend (proprietary)
pregnenolone
probiotics
Pulsatilla
Purple Monkeyflower
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
Rhodiola
rosavins
rosmarinic acid
Safranal
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Sandalwood
sceletium
Scleranthus annus
Shankhpushpi
shen-chu
skullcap
Spikenard
St. John's Wort
star of Bethlehem
Tea
Terpenoids
Tetrahydropalmatine
Trichilia catigua
Valerenic acid
Valerian root
velvet bean
Vervain
vitamin B
vitamin B12
vitamin B6
Vitexin
Waterhyssop
Wogonin
Yohimbine
Zinc