Evidence supporting the use of: Lactobacillus rhamnosus
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus rhamnosus is a probiotic bacterium that has gained research interest for its potential effects on mental health, particularly anxiety disorders. The rationale behind its use is based on the concept of the "gut-brain axis"—a bidirectional communication pathway between the gastrointestinal tract and the central nervous system. Several preclinical studies in animal models have demonstrated that L. rhamnosus supplementation can influence behavior and neurochemistry associated with anxiety. Notably, a widely cited 2011 study by Bravo et al. found that mice given L. rhamnosus exhibited reduced anxiety- and depression-related behaviors, potentially through modulation of GABA receptor expression and vagus nerve signaling.

Human evidence, however, remains limited. A handful of small-scale clinical trials have explored the effects of L. rhamnosus on stress and mood, with some suggesting modest benefits but others showing no significant effects. Systematic reviews and meta-analyses generally conclude that while probiotics may have a positive impact on subjective stress and mood, the specific effects of L. rhamnosus on clinically diagnosed anxiety disorders in humans have not been conclusively demonstrated. The evidence quality is limited by small sample sizes, short study durations, and heterogeneity in study design.

In summary, while L. rhamnosus shows promise in preclinical models and is the subject of ongoing research, robust scientific validation in humans is currently lacking, resulting in a low-to-moderate evidence rating for its use in supporting or treating anxiety disorders.

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Other ingredients used for Anxiety Disorders

5-Hydroxytryptophan (5-HTP)
amino acids
ashwagandha
waterhyssop
beta caryophyllene
bifidobacterium infantis
bifidobacterium longum
cannabis sativa oil
chamomile
citrus oil
curcumin
ginkgo biloba
ginseng
gotu kola
green tea
hemp oil
inositol
kava
L-glycine
L-taurine
L-theanine
L-tryptophan
lactium casein decapeptide
lactobacillus casei
lactobacillus paracasei
lactobacillus rhamnosus
lavender
lion's mane
lithium orotate
magnesium
magnolia
matcha
melatonin
motherwort
muira puama
n-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
phosphatidylserine
phytocannabinoids
polygala root
prebiotic blend (proprietary)
pregnenolone
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
rhodiola
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sceletium
skullcap
valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
zinc
catnip
shen-chu
St. John's Wort
herbal blend (proprietary)
cocoa
star of Bethlehem
7,8-Dihydroxyflavone
Apigenin
Albizia
Aconite
Baikal Skullcap
Bifidobacterium adolescentis
Bacopin
Brahmi
Bacopa
bacoside
Clary sage
Cymbopogon Martini
Centella asiatica
Capitate Valerian
Cowslip
Cannabidiol
Convolvulus prostratus
Convolvulus Pluricaulis
Essential Oil Blend
Gelsemium
Griffonia simplicifolia
Ginkgoside
Gastrodin
Honokiol
Hypericum
hyperforin
Hericium mushroom
Hemp
Jujubosides
Kavalactones
Kefir
lemon balm
Linden
Lactococcus rhamnosus
Lavandin
Large-Leaved Linden
Lactobacillus
Linalool
Mimulus
Monoterpenes
Magnolol
Mulungu
Mesembrine
Pulsatilla
Probiotics
Passionfruit
Polygala
Purple Monkeyflower
Rosavins
Rosmarinic Acid
Spikenard
Scleranthus annus
Shankhpushpi
Sandalwood
Saffranal
Terpenoids
Tea
Trichilia catigua
Tetrahydropalmatine
Valerenic acid
Vervain
Vitexin
Wogonin
yohimbine