Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lion’s mane mushroom (Hericium erinaceus) has gained popularity as a natural supplement purported to support cognitive health and reduce symptoms of anxiety and depression. The scientific evidence supporting its use for anxiety disorders is preliminary but growing. Several animal studies have shown that extracts from lion’s mane can promote neurogenesis (the growth of new neurons) and enhance levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), both of which are important for brain health and may play a role in mood regulation.

A small number of human studies have been conducted. For example, a 2010 double-blind, placebo-controlled study in postmenopausal women found that those taking lion’s mane cookies for four weeks reported reduced feelings of anxiety and irritation compared to controls. However, this study was limited by its small sample size and short duration. Other clinical research is sparse, and most available studies focus on combined symptoms of anxiety and depression rather than anxiety disorders alone.

While the biological plausibility for lion’s mane affecting mood is supported by animal data and a handful of small clinical trials, robust evidence from large, well-designed human studies is lacking. Therefore, its use for anxiety disorders is supported by some early scientific findings, but the overall quality and quantity of evidence are currently low.

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