Evidence supporting the use of: Magnesiium
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Magnesium has been investigated as a potential adjunct in the management of anxiety disorders, and its use is supported by both mechanistic rationale and some clinical evidence, though the overall strength of evidence is limited. Magnesium is involved in numerous biochemical pathways in the brain, including the regulation of the hypothalamic-pituitary-adrenal (HPA) axis and modulation of NMDA receptors, both of which have been implicated in anxiety. Observational studies have noted that individuals with low magnesium intake or serum levels are more likely to report symptoms of anxiety. Some small randomized controlled trials and meta-analyses suggest that magnesium supplementation may reduce subjective anxiety, particularly in individuals with pre-existing deficiencies or in those experiencing mild anxiety symptoms. However, the majority of these studies are small, heterogeneous, and often include participants without formal anxiety disorder diagnoses. A 2017 systematic review (Boyle et al., 2017) concluded that existing evidence is suggestive but not definitive, and that larger, high-quality trials are necessary. In summary, while there is plausible scientific support and some preliminary clinical evidence for magnesium supplementation in anxiety, the overall evidence base is weak, and it is not considered a first-line treatment for anxiety disorders.

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Products containing Magnesiium

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