Evidence supporting the use of: Magnesium threonate
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Magnesium threonate is a compound formed from magnesium and L-threonic acid, developed primarily for its ability to increase magnesium levels in the brain more effectively than other forms of magnesium. There is some emerging scientific interest in magnesium threonate for neurological and psychiatric conditions, including anxiety disorders, due to magnesium's general role in neural regulation, neurotransmitter balance, and neuroplasticity. However, the direct evidence for magnesium threonate specifically in the treatment or support of anxiety disorders is limited and preliminary.

Most available research focuses on animal models or small-scale human studies, which suggest that magnesium supplementation may have an anxiolytic (anxiety-reducing) effect, likely mediated by its influence on NMDA receptors, glutamatergic transmission, and the hypothalamic-pituitary-adrenal (HPA) axis. The most notable human study of magnesium threonate (Liu et al., 2016) focused on cognitive decline rather than anxiety. There are no large, high-quality randomized controlled trials directly demonstrating that magnesium threonate alleviates anxiety symptoms in humans.

In summary, while there is a theoretical basis and some indirect evidence for magnesium’s role in anxiety modulation, the specific use of magnesium threonate for anxiety disorders is supported by only low-level scientific evidence at this time. More rigorous clinical trials are needed before it can be considered a validated treatment for anxiety.

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