Evidence supporting the use of: N-acetylcysteine
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

N-acetylcysteine (NAC) has been investigated as a potential adjunctive treatment for anxiety disorders, but the evidence remains preliminary and limited. NAC is a precursor to the antioxidant glutathione and is thought to influence glutamatergic and oxidative pathways, both of which have been implicated in the pathophysiology of anxiety disorders. Small randomized controlled trials (RCTs) and open-label studies have assessed NAC in populations with comorbid anxiety and other psychiatric conditions (such as obsessive-compulsive disorder, bipolar disorder, and substance use). Some studies report modest reductions in anxiety symptoms, but these effects are not consistent or robust across the literature. Systematic reviews and meta-analyses (e.g., Deepmala et al., 2015, and Minarini et al., 2017) note that while NAC appears safe and may have some beneficial effects on mood and anxiety-related symptoms, the evidence is insufficient to recommend its routine use for primary anxiety disorders. Most studies are small, have methodological limitations, and often include participants with multiple comorbidities, making it difficult to isolate effects on pure anxiety disorders. At present, NAC is not a first-line treatment for anxiety, but ongoing research may clarify its role as an adjunctive therapy in the future.

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Other ingredients used for Anxiety Disorders

5-Hydroxytryptophan (5-HTP)
amino acids
ashwagandha
waterhyssop
beta caryophyllene
bifidobacterium infantis
bifidobacterium longum
cannabis sativa oil
chamomile
citrus oil
curcumin
ginkgo biloba
ginseng
gotu kola
green tea
hemp oil
inositol
kava
L-glycine
L-taurine
L-theanine
L-tryptophan
lactium casein decapeptide
lactobacillus casei
lactobacillus paracasei
lactobacillus rhamnosus
lavender
lion's mane
lithium orotate
magnesium
magnolia
matcha
melatonin
motherwort
muira puama
n-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
phosphatidylserine
phytocannabinoids
polygala root
prebiotic blend (proprietary)
pregnenolone
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
rhodiola
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sceletium
skullcap
valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
zinc
catnip
shen-chu
St. John's Wort
herbal blend (proprietary)
cocoa
star of Bethlehem
7,8-Dihydroxyflavone
Apigenin
Albizia
Aconite
Baikal Skullcap
Bifidobacterium adolescentis
Bacopin
Brahmi
Bacopa
bacoside
Clary sage
Cymbopogon Martini
Centella asiatica
Capitate Valerian
Cowslip
Cannabidiol
Convolvulus prostratus
Convolvulus Pluricaulis
Essential Oil Blend
Gelsemium
Griffonia simplicifolia
Ginkgoside
Gastrodin
Honokiol
Hypericum
hyperforin
Hericium mushroom
Hemp
Jujubosides
Kavalactones
Kefir
lemon balm
Linden
Lactococcus rhamnosus
Lavandin
Large-Leaved Linden
Lactobacillus
Linalool
Mimulus
Monoterpenes
Magnolol
Mulungu
Mesembrine
Pulsatilla
Probiotics
Passionfruit
Polygala
Purple Monkeyflower
Rosavins
Rosmarinic Acid
Spikenard
Scleranthus annus
Shankhpushpi
Sandalwood
Saffranal
Terpenoids
Tea
Trichilia catigua
Tetrahydropalmatine
Valerenic acid
Vervain
Vitexin
Wogonin
yohimbine

Products containing N-acetylcysteine

We currently have no products on Vitabase that contain this ingredient.