Evidence supporting the use of: Polygala
For the health condition: Anxiety Disorders
Synopsis
Source of validity: Traditional
Rating (out of 5): 2
Polygala, particularly Polygala tenuifolia (often called Yuan Zhi in traditional Chinese medicine), has been used historically as a remedy for anxiety, insomnia, and other nervous system disorders. Its use is rooted in centuries-old medical texts in East Asia, where it is described as a “calm spirit” herb believed to nourish the heart and mind. While there is a robust tradition of its use for what modern medicine might classify as anxiety disorders, direct scientific validation remains limited. Preliminary preclinical studies have shown that certain extracts of Polygala may exert anxiolytic-like effects in animal models, potentially via modulation of neurotransmitter systems such as GABA and monoamines. However, clinical trials in humans are sparse, low in quality, or non-existent, making it difficult to confidently assess its efficacy or safety for treating anxiety disorders by modern standards. As such, while the traditional use is well-documented, scientific support is still emerging and insufficient for firm recommendations.
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ashwagandha
waterhyssop
beta caryophyllene
bifidobacterium infantis
bifidobacterium longum
cannabis sativa oil
chamomile
citrus oil
curcumin
ginkgo biloba
ginseng
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hemp oil
inositol
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L-glycine
L-taurine
L-theanine
L-tryptophan
lactium casein decapeptide
lactobacillus casei
lactobacillus paracasei
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matcha
melatonin
motherwort
muira puama
n-acetyl-cysteine (NAC)
omega-3 fatty acids
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phosphatidylserine
phytocannabinoids
polygala root
prebiotic blend (proprietary)
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Ginkgoside
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