A Proprietary Blend (Herb/Botanical) is a term used to describe a mixture of herbal or botanical ingredients, with exact quantities kept confidential by manufacturers. The use of herbal blends to support or treat anxiety disorders is primarily justified by traditional use rather than robust scientific validation. Many cultures have used plants such as valerian root, passionflower, kava, chamomile, and others for centuries to promote relaxation and reduce anxiety symptoms. Historical records and traditional medical systems, such as Traditional Chinese Medicine and Ayurveda, have documented the use of various herbs for calming effects. However, scientific research on proprietary blends specifically is limited, as most studies focus on individual herbs rather than combinations. Some individual components, such as kava or valerian, have moderate evidence supporting their anxiolytic effects, but comprehensive, large-scale, placebo-controlled trials on proprietary blends as a whole are lacking. Furthermore, the lack of transparency in ingredient quantities makes it difficult to evaluate efficacy and safety. Regulatory agencies such as the FDA do not require pre-market testing of these blends, and safety concerns exist for certain botanicals (e.g., kava's association with liver toxicity). In summary, while the traditional use of various herbs for anxiety is well-documented, strong scientific evidence for the efficacy and safety of proprietary herbal blends in treating anxiety disorders remains limited, and they should be used with caution.