Evidence supporting the use of: Pyridoxine (Vitamin B6)
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pyridoxine (Vitamin B6) has been investigated for its potential role in supporting or treating anxiety disorders, primarily due to its involvement in neurotransmitter synthesis. Vitamin B6 acts as a cofactor in the biosynthesis of gamma-aminobutyric acid (GABA), serotonin, and dopamine—neurotransmitters implicated in mood regulation and anxiety. Several small clinical studies and observational data have explored the relationship between B6 status and anxiety symptoms. For example, a 2022 randomized, placebo-controlled trial found that high-dose B6 supplementation modestly reduced self-reported anxiety levels in young adults, possibly through enhanced GABAergic activity, though the effect size was small and the study duration short.

Despite these findings, the overall scientific evidence remains limited and inconsistent. Most studies to date are small, use self-reported outcomes, and do not establish causality. Meta-analyses and systematic reviews generally conclude that while there is biological plausibility for B6’s involvement in anxiety pathways, robust clinical evidence is lacking, and supplementation is not a standard or widely recommended treatment for anxiety disorders. Current guidelines do not recommend B6 as a primary or adjunctive therapy for anxiety. Thus, while scientific rationale exists and preliminary data are somewhat promising, the strength of evidence is modest at best, warranting a rating of 2.

More about Pyridoxine (Vitamin B6)
More about Anxiety Disorders

Other ingredients used for Anxiety Disorders

5-Hydroxytryptophan (5-HTP)
amino acids
ashwagandha
waterhyssop
beta caryophyllene
bifidobacterium infantis
bifidobacterium longum
cannabis sativa oil
chamomile
citrus oil
curcumin
ginkgo biloba
ginseng
gotu kola
green tea
hemp oil
inositol
kava
L-glycine
L-taurine
L-theanine
L-tryptophan
lactium casein decapeptide
lactobacillus casei
lactobacillus paracasei
lactobacillus rhamnosus
lavender
lion's mane
lithium orotate
magnesium
magnolia
matcha
melatonin
motherwort
muira puama
n-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
phosphatidylserine
phytocannabinoids
polygala root
prebiotic blend (proprietary)
pregnenolone
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
rhodiola
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sceletium
skullcap
valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
zinc
catnip
shen-chu
St. John's Wort
herbal blend (proprietary)
cocoa
star of Bethlehem
7,8-Dihydroxyflavone
Apigenin
Albizia
Aconite
Baikal Skullcap
Bifidobacterium adolescentis
Bacopin
Brahmi
Bacopa
bacoside
Clary sage
Cymbopogon Martini
Centella asiatica
Capitate Valerian
Cowslip
Cannabidiol
Convolvulus prostratus
Convolvulus Pluricaulis
Essential Oil Blend
Gelsemium
Griffonia simplicifolia
Ginkgoside
Gastrodin
Honokiol
Hypericum
hyperforin
Hericium mushroom
Hemp
Jujubosides
Kavalactones
Kefir
lemon balm
Linden
Lactococcus rhamnosus
Lavandin
Large-Leaved Linden
Lactobacillus
Linalool
Mimulus
Monoterpenes
Magnolol
Mulungu
Mesembrine
Pulsatilla
Probiotics
Passionfruit
Polygala
Purple Monkeyflower
Rosavins
Rosmarinic Acid
Spikenard
Scleranthus annus
Shankhpushpi
Sandalwood
Saffranal
Terpenoids
Tea
Trichilia catigua
Tetrahydropalmatine
Valerenic acid
Vervain
Vitexin
Wogonin
yohimbine

Products containing Pyridoxine (Vitamin B6)

We currently have no products on Vitabase that contain this ingredient.