Evidence supporting the use of: Rosmarinic acid
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Rosmarinic acid, a polyphenolic compound found in various culinary herbs such as rosemary, basil, and lemon balm, has been investigated for its potential anxiolytic (anxiety-reducing) effects. Preclinical studies, particularly animal models, have shown that rosmarinic acid may modulate neurotransmitter systems associated with anxiety, such as GABAergic and serotonergic pathways. For example, several rodent studies have demonstrated reduced anxiety-like behaviors following administration of rosmarinic acid or extracts rich in this compound, often attributed to its antioxidant and anti-inflammatory properties as well as modulation of the central nervous system.

However, robust clinical evidence in humans is limited. Preliminary human studies, typically involving combinations of rosmarinic acid-containing herbs (like lemon balm), suggest some potential for reducing symptoms of mild anxiety, but these studies often lack rigorous controls or use small sample sizes. No large-scale, high-quality randomized controlled trials have directly evaluated isolated rosmarinic acid for anxiety disorders.

In summary, while there is a scientific rationale and supportive animal data for using rosmarinic acid to address anxiety, current evidence from human studies is weak and not sufficient to firmly establish efficacy. Thus, the overall evidence rating is 2 out of 5, reflecting promising but preliminary support for its use in anxiety disorders.

More about rosmarinic acid
More about Anxiety Disorders

Other ingredients used for Anxiety Disorders

5-Hydroxytryptophan (5-HTP)
7,8-Dihydroxyflavone
Aconite
Albizia
amino acids
apigenin
ashwagandha
Bacopa
Bacopin
bacoside
Baikal Skullcap
beta caryophyllene
Bifidobacterium adolescentis
Bifidobacterium infantis
Bifidobacterium longum
brahmi
cannabidiol
Cannabis sativa oil
Capitate Valerian
catnip
Centella asiatica
chamomile
Clary sage
cocoa
Convolvulus pluricaulis
Convolvulus prostratus
cowslip
curcumin
Cymbopogon martini
essential oil blend
gastrodin
Gelsemium
ginkgo biloba
Ginkgoside
ginseng
gotu kola
green tea
Griffonia simplicifolia
hemp
hemp oil
herbal blend (proprietary)
hericium mushroom
Honokiol
hyperforin
Hypericum
inositol
jujubosides
kava
kavalactones
Kefir
L-glycine
L-taurine
L-theanine
L-tryptophan
lactium casein decapeptide
Lactobacillus
Lactobacillus casei
Lactobacillus paracasei
Lactobacillus rhamnosus
Lactococcus rhamnosus
Large-leaved linden
Lavandin
lavender
lemon balm
linalool
linden
lion's mane
lithium orotate
magnesium
magnolia
magnolol
Matcha
Melatonin
Mesembrine
Mimulus
Monoterpenes
Motherwort
Muira puama
Mulungu
N-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
Passionfruit
phosphatidylserine
phytocannabinoids
Polygala
polygala root
prebiotic blend (proprietary)
pregnenolone
probiotics
Pulsatilla
Purple Monkeyflower
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
Rhodiola
rosavins
rosmarinic acid
Safranal
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Sandalwood
sceletium
Scleranthus annus
Shankhpushpi
shen-chu
skullcap
Spikenard
St. John's Wort
star of Bethlehem
Tea
Terpenoids
Tetrahydropalmatine
Trichilia catigua
Valerenic acid
Valerian root
velvet bean
Vervain
vitamin B
vitamin B12
vitamin B6
Vitexin
Waterhyssop
Wogonin
Yohimbine
Zinc

Products containing rosmarinic acid

We currently have no products on Vitabase that contain this ingredient.