Evidence supporting the use of: Rosmarinic Acid
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Rosmarinic acid, a polyphenolic compound found in various culinary herbs such as rosemary, basil, and lemon balm, has been investigated for its potential anxiolytic (anxiety-reducing) effects. Preclinical studies, particularly animal models, have shown that rosmarinic acid may modulate neurotransmitter systems associated with anxiety, such as GABAergic and serotonergic pathways. For example, several rodent studies have demonstrated reduced anxiety-like behaviors following administration of rosmarinic acid or extracts rich in this compound, often attributed to its antioxidant and anti-inflammatory properties as well as modulation of the central nervous system.

However, robust clinical evidence in humans is limited. Preliminary human studies, typically involving combinations of rosmarinic acid-containing herbs (like lemon balm), suggest some potential for reducing symptoms of mild anxiety, but these studies often lack rigorous controls or use small sample sizes. No large-scale, high-quality randomized controlled trials have directly evaluated isolated rosmarinic acid for anxiety disorders.

In summary, while there is a scientific rationale and supportive animal data for using rosmarinic acid to address anxiety, current evidence from human studies is weak and not sufficient to firmly establish efficacy. Thus, the overall evidence rating is 2 out of 5, reflecting promising but preliminary support for its use in anxiety disorders.

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