Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Saffranal, a bioactive compound found in saffron (Crocus sativus), has been investigated for its potential anxiolytic (anxiety-reducing) effects. Several preclinical studies in animal models suggest that saffranal may exert anxiolytic-like effects, possibly via modulation of GABAergic and serotonergic systems—mechanisms also targeted by conventional anti-anxiety medications. For example, rodent studies have demonstrated that administration of saffranal can reduce anxiety-like behaviors in standardized tests such as the elevated plus maze. Some small clinical trials of saffron extracts (which contain saffranal as one component) have also reported reductions in anxiety symptoms in humans compared to placebo; however, these studies typically assess whole saffron extracts rather than isolated saffranal, making it difficult to attribute effects specifically to this compound. Overall, while there is preliminary scientific evidence—mainly from animal studies and a few human studies involving saffron extracts—supporting the anxiolytic effects of saffranal, the evidence is still limited and not robust enough to warrant strong clinical recommendations. Larger, well-designed clinical trials are needed to clarify its efficacy and safety in treating anxiety disorders.

More about Safranal
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Other ingredients used for Anxiety Disorders

5-Hydroxytryptophan (5-HTP)
7,8-Dihydroxyflavone
Aconite
Albizia
amino acids
apigenin
ashwagandha
Bacopa
Bacopin
bacoside
Baikal Skullcap
beta caryophyllene
Bifidobacterium adolescentis
Bifidobacterium infantis
Bifidobacterium longum
brahmi
cannabidiol
Cannabis sativa oil
Capitate Valerian
catnip
Centella asiatica
chamomile
Clary sage
cocoa
Convolvulus pluricaulis
Convolvulus prostratus
cowslip
curcumin
Cymbopogon martini
essential oil blend
gastrodin
Gelsemium
ginkgo biloba
Ginkgoside
ginseng
gotu kola
green tea
Griffonia simplicifolia
hemp
hemp oil
herbal blend (proprietary)
hericium mushroom
Honokiol
hyperforin
Hypericum
inositol
jujubosides
kava
kavalactones
Kefir
L-glycine
L-taurine
L-theanine
L-tryptophan
lactium casein decapeptide
Lactobacillus
Lactobacillus casei
Lactobacillus paracasei
Lactobacillus rhamnosus
Lactococcus rhamnosus
Large-leaved linden
Lavandin
lavender
lemon balm
linalool
linden
lion's mane
lithium orotate
magnesium
magnolia
magnolol
Matcha
Melatonin
Mesembrine
Mimulus
Monoterpenes
Motherwort
Muira puama
Mulungu
N-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
Passionfruit
phosphatidylserine
phytocannabinoids
Polygala
polygala root
prebiotic blend (proprietary)
pregnenolone
probiotics
Pulsatilla
Purple Monkeyflower
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
Rhodiola
rosavins
rosmarinic acid
Safranal
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Sandalwood
sceletium
Scleranthus annus
Shankhpushpi
shen-chu
skullcap
Spikenard
St. John's Wort
star of Bethlehem
Tea
Terpenoids
Tetrahydropalmatine
Trichilia catigua
Valerenic acid
Valerian root
velvet bean
Vervain
vitamin B
vitamin B12
vitamin B6
Vitexin
Waterhyssop
Wogonin
Yohimbine
Zinc

Other health conditions supported by Safranal

Alzheimer's Disease
Anxiety
Anxiety Disorders
Depression
Insomnia
Memory and Brain Function
Stress

Products containing Safranal

We currently have no products on Vitabase that contain this ingredient.