Evidence supporting the use of: Terpene
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Terpenes are a large and diverse class of organic compounds produced by many plants, including cannabis. Certain terpenes, such as linalool (found in lavender), limonene (found in citrus peels), and beta-caryophyllene (found in black pepper and other spices), have been studied for their potential anxiolytic (anxiety-reducing) effects. Preclinical studies—mainly in animal models—suggest that these terpenes can interact with neurotransmitter systems implicated in anxiety disorders, such as the GABAergic and serotonergic systems. For example, linalool has shown anxiolytic effects in rodents, and limonene has exhibited similar properties in animal studies.

Human clinical evidence is limited and primarily consists of small pilot studies or indirect evidence (e.g., aromatherapy studies with lavender oil, which contains linalool). While these results are promising, there is insufficient high-quality, large-scale clinical research to conclusively confirm the effectiveness of terpenes for treating anxiety disorders in humans. As a result, the scientific evidence supporting the use of terpenes for anxiety is preliminary and rates as low to moderate (2/5). More rigorous human clinical trials are needed to establish efficacy, safety, dosing, and mechanisms of action.

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Products containing Terpene

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