Evidence supporting the use of: Terpenoids
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Terpenoids, also known as isoprenoids, are a large and diverse class of naturally occurring organic chemicals derived from terpenes. They are found in many plants, including those used in traditional herbal remedies for anxiety, such as lavender and cannabis. Scientific interest in terpenoids has grown due to their presence in essential oils and their potential effects on the central nervous system.

Several terpenoids, such as linalool (found in lavender) and beta-caryophyllene (found in black pepper and cannabis), have been studied for their anxiolytic (anxiety-reducing) properties. Preclinical studies, primarily in animal models, suggest that some terpenoids may modulate neurotransmitter systems involved in anxiety, such as the GABAergic and endocannabinoid systems. For example, linalool has demonstrated anxiolytic-like effects in rodents, which may be mediated by interactions with GABAA receptors. Beta-caryophyllene has shown similar effects, potentially via CB2 receptor activation.

However, human clinical evidence remains limited. Most studies are small, preliminary, or based on inhalation of essential oils rather than isolated terpenoids. While traditional use and animal studies provide a rationale for further research, current scientific evidence supporting the use of terpenoids for anxiety disorders in humans is low to moderate. Well-designed clinical trials are needed to confirm both efficacy and safety.

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