Evidence supporting the use of: Tetrahydropalmatine
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Tetrahydropalmatine (THP) is an isoquinoline alkaloid isolated from several plant species, including Corydalis yanhusuo, widely used in traditional Chinese medicine. In recent years, preclinical studies have explored its potential anxiolytic effects. Animal research has shown that THP exhibits anxiolytic-like activity in behavioral models, such as the elevated plus maze and open field test. The proposed mechanism involves modulation of dopaminergic and GABAergic neurotransmission, as THP is known to act as a dopamine receptor antagonist and may influence GABA receptors, both relevant to anxiety regulation. While these findings are promising, human clinical trials are extremely limited. A few small-scale studies and case reports suggest some benefit for anxiety and related symptoms, but robust, placebo-controlled clinical trials are lacking. Thus, although there is a scientific rationale for THP’s use in anxiety disorders, the evidence is primarily preclinical, and no major health authorities endorse its use for this indication. Most systematic reviews and expert opinions characterize the evidence as preliminary. In summary, there is some scientific basis for exploring THP in the treatment of anxiety disorders, largely supported by animal data and mechanistic plausibility. However, the current clinical evidence is weak and insufficient to justify routine use in humans for anxiety disorders.

More about Tetrahydropalmatine
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Other ingredients used for Anxiety Disorders

5-Hydroxytryptophan (5-HTP)
7,8-Dihydroxyflavone
Aconite
Albizia
amino acids
apigenin
ashwagandha
Bacopa
Bacopin
bacoside
Baikal Skullcap
beta caryophyllene
Bifidobacterium adolescentis
Bifidobacterium infantis
Bifidobacterium longum
brahmi
cannabidiol
Cannabis sativa oil
Capitate Valerian
catnip
Centella asiatica
chamomile
Clary sage
cocoa
Convolvulus pluricaulis
Convolvulus prostratus
cowslip
curcumin
Cymbopogon martini
essential oil blend
gastrodin
Gelsemium
ginkgo biloba
Ginkgoside
ginseng
gotu kola
green tea
Griffonia simplicifolia
hemp
hemp oil
herbal blend (proprietary)
hericium mushroom
Honokiol
hyperforin
Hypericum
inositol
jujubosides
kava
kavalactones
Kefir
L-glycine
L-taurine
L-theanine
L-tryptophan
lactium casein decapeptide
Lactobacillus
Lactobacillus casei
Lactobacillus paracasei
Lactobacillus rhamnosus
Lactococcus rhamnosus
Large-leaved linden
Lavandin
lavender
lemon balm
linalool
linden
lion's mane
lithium orotate
magnesium
magnolia
magnolol
Matcha
Melatonin
Mesembrine
Mimulus
Monoterpenes
Motherwort
Muira puama
Mulungu
N-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
Passionfruit
phosphatidylserine
phytocannabinoids
Polygala
polygala root
prebiotic blend (proprietary)
pregnenolone
probiotics
Pulsatilla
Purple Monkeyflower
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
Rhodiola
rosavins
rosmarinic acid
Safranal
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Sandalwood
sceletium
Scleranthus annus
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shen-chu
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Spikenard
St. John's Wort
star of Bethlehem
Tea
Terpenoids
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Trichilia catigua
Valerenic acid
Valerian root
velvet bean
Vervain
vitamin B
vitamin B12
vitamin B6
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Products containing Tetrahydropalmatine

We currently have no products on Vitabase that contain this ingredient.