Evidence supporting the use of: Uncaria rhynchophylla
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Uncaria rhynchophylla, commonly known as Gou Teng, has been used in traditional Chinese medicine primarily for calming the liver, extinguishing wind, and treating conditions such as headaches, dizziness, hypertension, and certain neurological symptoms. Its use for anxiety disorders is based on its reputed sedative and neuroprotective effects, but direct historical claims of treating "anxiety" per se are not clear-cut. Rather, it has been used to alleviate symptoms that may overlap with anxiety, such as agitation, restlessness, and insomnia.

Scientific studies on Uncaria rhynchophylla have focused mainly on its alkaloid content (notably rhynchophylline) and its neuroprotective and anti-convulsant properties. Some animal studies have suggested anxiolytic-like effects, such as reduced exploratory anxiety behaviors in rodents, possibly mediated by modulation of NMDA and serotonergic systems. However, robust clinical trials in humans for anxiety disorders are lacking, and most available data are preclinical or extrapolated from its general calming effects.

In summary, the justification for using Uncaria rhynchophylla in anxiety disorders is primarily traditional, with some preliminary scientific rationale but insufficient direct evidence. Its efficacy for this specific indication is not well established by modern research.

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