Evidence supporting the use of: Vitamin B6 (not specified)
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6, also known as pyridoxine, has been investigated for its potential role in supporting mental health, including anxiety disorders. The scientific evidence for its use is limited but not absent. Some small-scale studies and biochemical rationale suggest that Vitamin B6 may contribute to neurotransmitter synthesis (such as serotonin, dopamine, and GABA), which are involved in mood regulation and anxiety. For example, a 2022 randomized controlled trial (RCT) published in Human Psychopharmacology found that high-dose Vitamin B6 supplementation (100 mg/day for one month) significantly reduced self-reported anxiety and stress compared to placebo in young adults. The authors hypothesized this effect was due to enhanced GABAergic activity, as B6 is a cofactor in GABA synthesis. However, these findings have not been widely replicated, and the overall body of evidence is sparse, with most studies being small and short-term.

There is also some evidence that individuals with anxiety may have lower B6 status, but causality and clinical significance remain unclear. Major guidelines do not currently recommend Vitamin B6 as a primary or adjunctive treatment for anxiety disorders. Thus, while there is a plausible mechanism and some preliminary human data, the use of Vitamin B6 for anxiety is not strongly supported and merits a low evidence rating.

More about Vitamin B6 (not specified)
More about Anxiety Disorders

Other ingredients used for Anxiety Disorders

5-Hydroxytryptophan (5-HTP)
amino acids
ashwagandha
waterhyssop
beta caryophyllene
bifidobacterium infantis
bifidobacterium longum
cannabis sativa oil
chamomile
citrus oil
curcumin
ginkgo biloba
ginseng
gotu kola
green tea
hemp oil
inositol
kava
L-glycine
L-taurine
L-theanine
L-tryptophan
lactium casein decapeptide
lactobacillus casei
lactobacillus paracasei
lactobacillus rhamnosus
lavender
lion's mane
lithium orotate
magnesium
magnolia
matcha
melatonin
motherwort
muira puama
n-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
phosphatidylserine
phytocannabinoids
polygala root
prebiotic blend (proprietary)
pregnenolone
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
rhodiola
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sceletium
skullcap
valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
zinc
catnip
shen-chu
St. John's Wort
herbal blend (proprietary)
cocoa
star of Bethlehem
7,8-Dihydroxyflavone
Apigenin
Albizia
Aconite
Baikal Skullcap
Bifidobacterium adolescentis
Bacopin
Brahmi
Bacopa
bacoside
Clary sage
Cymbopogon Martini
Centella asiatica
Capitate Valerian
Cowslip
Cannabidiol
Convolvulus prostratus
Convolvulus Pluricaulis
Essential Oil Blend
Gelsemium
Griffonia simplicifolia
Ginkgoside
Gastrodin
Honokiol
Hypericum
hyperforin
Hericium mushroom
Hemp
Jujubosides
Kavalactones
Kefir
lemon balm
Linden
Lactococcus rhamnosus
Lavandin
Large-Leaved Linden
Lactobacillus
Linalool
Mimulus
Monoterpenes
Magnolol
Mulungu
Mesembrine
Pulsatilla
Probiotics
Passionfruit
Polygala
Purple Monkeyflower
Rosavins
Rosmarinic Acid
Spikenard
Scleranthus annus
Shankhpushpi
Sandalwood
Saffranal
Terpenoids
Tea
Trichilia catigua
Tetrahydropalmatine
Valerenic acid
Vervain
Vitexin
Wogonin
yohimbine

Products containing Vitamin B6 (not specified)

We currently have no products on Vitabase that contain this ingredient.