Evidence supporting the use of: Vitamin B6 (pyridoxal)
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxal) has some scientific evidence supporting its use for anxiety disorders, though the evidence is limited and not robust. B6 is a cofactor in the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), all of which are implicated in mood regulation and anxiety. Some small clinical studies and case reports suggest that supplementation with vitamin B6 may help reduce symptoms of anxiety, particularly in individuals with suboptimal B6 levels. For example, a 2022 randomized controlled trial published in "Human Psychopharmacology" found that high-dose B6 supplementation reduced self-reported anxiety in young adults compared to placebo, though the effect size was modest and the study duration short. Other studies have found correlations between low B6 status and higher rates of anxiety, but a causal relationship has not been established.

Despite these findings, the overall quality of the evidence is low due to small sample sizes, short intervention durations, and a lack of replication in diverse populations. Major clinical guidelines do not currently recommend vitamin B6 as a primary or adjunctive treatment for anxiety disorders. Due to its role in neurotransmitter synthesis and some preliminary data, B6 is sometimes used as a complementary approach, but more rigorous research is necessary to confirm its efficacy and optimal use in anxiety treatment.

More about Vitamin B6 (pyridoxal)
More about Anxiety Disorders

Other ingredients used for Anxiety Disorders

5-Hydroxytryptophan (5-HTP)
amino acids
ashwagandha
waterhyssop
beta caryophyllene
bifidobacterium infantis
bifidobacterium longum
cannabis sativa oil
chamomile
citrus oil
curcumin
ginkgo biloba
ginseng
gotu kola
green tea
hemp oil
inositol
kava
L-glycine
L-taurine
L-theanine
L-tryptophan
lactium casein decapeptide
lactobacillus casei
lactobacillus paracasei
lactobacillus rhamnosus
lavender
lion's mane
lithium orotate
magnesium
magnolia
matcha
melatonin
motherwort
muira puama
n-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
phosphatidylserine
phytocannabinoids
polygala root
prebiotic blend (proprietary)
pregnenolone
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
rhodiola
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sceletium
skullcap
valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
zinc
catnip
shen-chu
St. John's Wort
herbal blend (proprietary)
cocoa
star of Bethlehem
7,8-Dihydroxyflavone
Apigenin
Albizia
Aconite
Baikal Skullcap
Bifidobacterium adolescentis
Bacopin
Brahmi
Bacopa
bacoside
Clary sage
Cymbopogon Martini
Centella asiatica
Capitate Valerian
Cowslip
Cannabidiol
Convolvulus prostratus
Convolvulus Pluricaulis
Essential Oil Blend
Gelsemium
Griffonia simplicifolia
Ginkgoside
Gastrodin
Honokiol
Hypericum
hyperforin
Hericium mushroom
Hemp
Jujubosides
Kavalactones
Kefir
lemon balm
Linden
Lactococcus rhamnosus
Lavandin
Large-Leaved Linden
Lactobacillus
Linalool
Mimulus
Monoterpenes
Magnolol
Mulungu
Mesembrine
Pulsatilla
Probiotics
Passionfruit
Polygala
Purple Monkeyflower
Rosavins
Rosmarinic Acid
Spikenard
Scleranthus annus
Shankhpushpi
Sandalwood
Saffranal
Terpenoids
Tea
Trichilia catigua
Tetrahydropalmatine
Valerenic acid
Vervain
Vitexin
Wogonin
yohimbine

Products containing Vitamin B6 (pyridoxal)

We currently have no products on Vitabase that contain this ingredient.