Evidence supporting the use of: Vitamin B6 (pyridoxal 5-phosphate)
For the health condition: Anxiety Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6, particularly in its active form pyridoxal 5'-phosphate (PLP), has some scientific rationale for its use in supporting anxiety disorders, though the evidence is limited and not robust. PLP is a coenzyme involved in the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA)—all of which play roles in mood regulation and anxiety. Some small-scale clinical studies and observational research suggest that low levels of vitamin B6 may be associated with increased risk of mood disorders, including anxiety. For example, a 2022 randomized controlled trial found that high-dose B6 supplementation modestly reduced self-reported anxiety levels, likely by boosting GABAergic activity. However, these findings are preliminary, and the sample sizes are small.

Most clinical guidelines do not recommend B6 as a first-line treatment for anxiety disorders, and systematic reviews highlight the need for larger, more rigorous studies to confirm benefits. While B6 is sometimes included in over-the-counter "stress support" supplements, its use is not based on strong clinical evidence but on its biochemical role in neurotransmitter synthesis. Thus, the scientific support is weak to moderate (rated 2 out of 5), with some plausible mechanisms and a few suggestive studies, but not enough to warrant widespread clinical use for anxiety on its own.

More about Vitamin B6 (pyridoxal 5-phosphate)
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Other ingredients used for Anxiety Disorders

5-Hydroxytryptophan (5-HTP)
amino acids
ashwagandha
waterhyssop
beta caryophyllene
bifidobacterium infantis
bifidobacterium longum
cannabis sativa oil
chamomile
citrus oil
curcumin
ginkgo biloba
ginseng
gotu kola
green tea
hemp oil
inositol
kava
L-glycine
L-taurine
L-theanine
L-tryptophan
lactium casein decapeptide
lactobacillus casei
lactobacillus paracasei
lactobacillus rhamnosus
lavender
lion's mane
lithium orotate
magnesium
magnolia
matcha
melatonin
motherwort
muira puama
n-acetyl-cysteine (NAC)
omega-3 fatty acids
passionflower
phosphatidylserine
phytocannabinoids
polygala root
prebiotic blend (proprietary)
pregnenolone
pyridoxal-5-phosphate (P-5-P)
reishi mushroom
relora® (proprietary)
rhodiola
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sceletium
skullcap
valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
zinc
catnip
shen-chu
St. John's Wort
herbal blend (proprietary)
cocoa
star of Bethlehem
7,8-Dihydroxyflavone
Apigenin
Albizia
Aconite
Baikal Skullcap
Bifidobacterium adolescentis
Bacopin
Brahmi
Bacopa
bacoside
Clary sage
Cymbopogon Martini
Centella asiatica
Capitate Valerian
Cowslip
Cannabidiol
Convolvulus prostratus
Convolvulus Pluricaulis
Essential Oil Blend
Gelsemium
Griffonia simplicifolia
Ginkgoside
Gastrodin
Honokiol
Hypericum
hyperforin
Hericium mushroom
Hemp
Jujubosides
Kavalactones
Kefir
lemon balm
Linden
Lactococcus rhamnosus
Lavandin
Large-Leaved Linden
Lactobacillus
Linalool
Mimulus
Monoterpenes
Magnolol
Mulungu
Mesembrine
Pulsatilla
Probiotics
Passionfruit
Polygala
Purple Monkeyflower
Rosavins
Rosmarinic Acid
Spikenard
Scleranthus annus
Shankhpushpi
Sandalwood
Saffranal
Terpenoids
Tea
Trichilia catigua
Tetrahydropalmatine
Valerenic acid
Vervain
Vitexin
Wogonin
yohimbine

Products containing Vitamin B6 (pyridoxal 5-phosphate)

We currently have no products on Vitabase that contain this ingredient.