Vitexin is a naturally occurring flavonoid glycoside found in various medicinal plants, such as passionflower (Passiflora incarnata) and hawthorn (Crataegus species). Its use in supporting anxiety disorders is primarily supported by preclinical scientific studies rather than long-standing traditional use. Several animal studies have reported that vitexin exhibits anxiolytic-like (anxiety-reducing) effects. These effects are often attributed to its modulation of neurotransmitter systems, particularly GABAergic and serotonergic pathways, which are also targeted by conventional anxiolytic drugs. For example, research published in Phytomedicine (2014) and Journal of Ethnopharmacology (2016) demonstrated that vitexin could reduce anxiety-like behaviors in mice subjected to stress models. The proposed mechanisms include antioxidant activity, anti-inflammatory effects, and direct interaction with neurotransmitter receptors.

However, it is important to note that the current evidence is limited to animal and in vitro studies. There is a lack of robust human clinical trials evaluating vitexin's efficacy and safety for treating anxiety disorders. Thus, while the compound shows promise based on preliminary scientific data, its use for anxiety in humans is not yet well validated. The evidence rating of 2 reflects this early-stage promise combined with the need for further research, particularly in clinical settings.