Evidence supporting the use of: Foxglove
For the health condition: Arrhythmia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Foxglove (Digitalis purpurea) is scientifically validated for use in treating certain types of arrhythmia, particularly atrial fibrillation and atrial flutter. The active compounds in foxglove, called cardiac glycosides (notably digoxin and digitoxin), have been used in medicine since the late 18th century after their effects on the heart were systematically described by William Withering. Cardiac glycosides increase the force of cardiac muscle contractions and slow conduction through the atrioventricular (AV) node, which can help control the ventricular rate in patients with supraventricular arrhythmias. Digoxin, derived directly from foxglove, is still used today as a prescription medication for heart failure and arrhythmias, though its use is more limited than in the past due to the narrow therapeutic index and potential for toxicity. Numerous clinical studies and decades of medical use have established the efficacy and pharmacology of digitalis compounds in arrhythmia management. However, because the margin between therapeutic and toxic doses is small, use is carefully monitored, and direct use of the plant (as opposed to standardized extracts or pure digoxin) is not recommended due to the risk of poisoning. In summary, the use of foxglove-derived compounds for certain arrhythmias is strongly supported by scientific evidence and remains a part of modern pharmacotherapy.

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Products containing Foxglove

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