Evidence supporting the use of: Magnesium citrate malate
For the health condition: Arrhythmia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Magnesium citrate malate is a supplemental form of magnesium commonly used to address magnesium deficiency, which can be associated with arrhythmias (irregular heart rhythms). There is scientific evidence supporting the role of magnesium in cardiac electrophysiology: magnesium is a cofactor for many enzymatic processes involved in myocardial cell membrane stability and electrical conduction. Hypomagnesemia (low magnesium levels) is a well-established risk factor for various arrhythmias, including premature ventricular contractions and torsades de pointes. Supplementation with magnesium, often as magnesium sulfate intravenously in acute care, is a standard therapy for certain arrhythmias, particularly those refractory to other treatments or associated with low serum magnesium.

Oral forms such as magnesium citrate and malate are used to maintain or replete magnesium levels in outpatient settings. While clinical trials specifically using magnesium citrate malate for arrhythmia are lacking, studies with general magnesium supplementation demonstrate some benefit, especially in patients with confirmed deficiency. However, evidence for magnesium supplementation as a treatment for arrhythmia in individuals with normal magnesium levels is limited and mixed. Thus, scientific justification exists, primarily in the context of deficiency, with a moderate evidence base (hence the rating of 3/5).

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