Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Alpha-Lipoic Acid (ALA) is a naturally occurring antioxidant that has been studied for its effects on cardiovascular health, particularly regarding its potential to support arterial function. Research suggests that ALA may improve endothelial function, reduce oxidative stress, and lower markers of inflammation, all of which are relevant to arterial health. Several clinical trials and animal studies have demonstrated that supplementation with ALA can improve vascular endothelial function, which is critical for the maintenance of healthy arteries. For example, a 2012 study published in Cardiovascular Diabetology found that ALA supplementation improved endothelial dysfunction in patients with metabolic syndrome.

ALA’s primary mechanism appears to involve the reduction of oxidative stress and the improvement of nitric oxide-mediated vasodilation, both of which are important for arterial flexibility and health. Some evidence also points to ALA’s ability to reduce LDL oxidation, a key contributor to atherosclerosis. However, while there is a reasonable body of preclinical and some clinical evidence, large-scale randomized controlled trials specifically targeting clinical cardiovascular outcomes in the general population are limited.

In summary, while traditional use is not prominent, there is scientific support—albeit moderate—for the use of Alpha-Lipoic Acid to support arterial health, primarily through its antioxidant and anti-inflammatory actions. Further research, especially long-term human trials, is needed to solidify these findings and determine optimal dosing and populations who may benefit most.

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Algae
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Allicin
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Alpha phytosterol
alpha-linolenic acid (ALA)
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Other body systems supported by alpha-lipoic acid

Arteries
Blood
Brain
Circulatory System
Heart
Hepatic System
Liver
Mitochondria
Nerves
Skin

Products containing alpha-lipoic acid

We currently have no products on Vitabase that contain this ingredient.