Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Citrulline silicate is a compound combining L-citrulline, a nonessential amino acid, and silicate. Its primary use in supplements is based on its ability to support nitric oxide (NO) production, which is crucial for vascular health and arterial function. Several studies on L-citrulline have shown that it can increase plasma arginine levels, leading to enhanced NO synthesis, vasodilation, and improved endothelial function. Improved NO availability is associated with better blood flow and reduced arterial stiffness, both of which are beneficial for cardiovascular and arterial health.

Research specifically on citrulline silicate is limited, but it is thought to provide similar or enhanced effects compared to L-citrulline alone, due to potentially improved bioavailability and the additional vascular-supportive properties of silicate. Preliminary studies and some small clinical trials have indicated that supplementation with citrulline or citrulline-containing compounds can reduce blood pressure in prehypertensive and hypertensive individuals, and improve arterial stiffness. However, data directly on citrulline silicate (as opposed to other salts or forms of citrulline) are sparse, with most evidence extrapolated from studies on L-citrulline.

In summary, while there is scientific rationale and some empirical support for the use of citrulline silicate to support arterial health—largely by promoting nitric oxide-mediated vasodilation—the direct evidence specific to citrulline silicate is still limited. The overall evidence warrants a moderate rating.

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Other body systems supported by Citrulline silicate

Arteries
Blood
Circulatory System
Heart
Muscles

Products containing Citrulline silicate

We currently have no products on Vitabase that contain this ingredient.