Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Diosmetin is a flavonoid aglycone primarily found as a metabolite of diosmin, which is derived from citrus fruits. Diosmin and its metabolite diosmetin have been studied for their vascular protective effects, particularly for supporting venous tone and reducing capillary permeability and fragility. Several clinical trials and reviews have evaluated the use of diosmin (often combined with hesperidin) in chronic venous insufficiency, hemorrhoids, and varicose veins. Diosmetin itself has demonstrated anti-inflammatory, antioxidant, and vasoprotective properties in preclinical studies, including inhibition of leukocyte adhesion and reduction of vascular permeability.

While most human studies have focused on diosmin, diosmetin is the primary active metabolite and is thought to mediate many of the beneficial effects observed. The evidence supporting its use for arterial health specifically is moderate, with some animal and in vitro studies indicating benefits such as improved endothelial function and reduced oxidative stress in arterial tissues. However, there are limited high-quality human clinical trials directly assessing diosmetin's effects on arterial health, so the evidence is not as robust as for venous disorders.

In summary, diosmetin is scientifically recognized for supporting vascular health, especially in the context of venous circulation. There is emerging but not definitive evidence for direct support of arterial function. Therefore, the use of diosmetin for arterial health is supported by moderate scientific evidence, primarily extrapolated from studies on diosmin and general vascular effects.

More about Diosmetin
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beet
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black currant
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citrus bioflavonoids
citrus pectin
citrus sinensis (proprietary)
coenzyme Q10 (CoQ10)
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
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Other body systems supported by Diosmetin

Arteries
Blood
Capillaries
Circulatory System
Veins

Products containing Diosmetin

We currently have no products on Vitabase that contain this ingredient.