Proprietary fruit blends commonly found in dietary supplements often consist of extracts or powders from fruits such as berries (e.g., blueberries, strawberries), grapes, pomegranates, and citrus fruits. Scientific evidence suggests that many of these fruits are rich in bioactive compounds, particularly polyphenols and flavonoids, which have been associated with vascular health benefits. Research indicates that these compounds can improve endothelial function, reduce oxidative stress, and decrease inflammation, all of which are beneficial for arterial health. For example, anthocyanins from berries and resveratrol from grapes have been shown in clinical and preclinical studies to help maintain healthy blood vessel function and support normal blood pressure.

However, while there is a reasonable scientific basis for the use of individual fruit extracts in supporting arterial health, the evidence for generic "proprietary fruit blends" is less robust. The efficacy depends on the types, concentrations, and bioavailability of the fruit components, which are often not fully disclosed in proprietary blends. Most supportive studies are on specific fruits or well-defined extracts, not on undefined mixtures. Therefore, while the overall concept is scientifically grounded, the direct evidence for the efficacy of specific proprietary fruit blends in supporting the arteries is moderate rather than strong.