Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-arginine is an amino acid that serves as a precursor to nitric oxide (NO), a key molecule involved in the relaxation and dilation of blood vessels (vasodilation). This mechanism is the primary reason for its use in supporting artery and cardiovascular health. Several clinical studies have demonstrated that L-arginine supplementation can improve endothelial function and increase NO production, particularly in individuals with endothelial dysfunction, such as those with hypertension or atherosclerosis. Randomized controlled trials have shown modest improvements in blood flow and arterial flexibility following L-arginine supplementation. However, evidence is mixed; some large-scale studies have failed to show significant cardiovascular benefits, and concerns exist regarding its use post-heart attack, where increased mortality was observed in one trial.

Despite varying results, the biological plausibility and mechanistic studies provide a scientific rationale for its use. Major reviews and meta-analyses conclude that while L-arginine may improve some markers of vascular health, the overall clinical benefit remains uncertain, especially for long-term cardiovascular outcomes. Therefore, L-arginine is rated as having moderate scientific support (3/5) for supporting arterial health, with stronger evidence for its effects on vascular function than on hard cardiovascular endpoints like heart attack or stroke.

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