Evidence supporting the use of: Lipoic Acid
For the body system: Arteries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lipoic acid, also known as alpha-lipoic acid (ALA), is an endogenous antioxidant that has been studied for its effects on vascular health, particularly due to its role in reducing oxidative stress and inflammation—both key contributors to arterial dysfunction and atherosclerosis. Several clinical and preclinical studies have investigated ALA’s impact on endothelial function, arterial stiffness, and overall cardiovascular risk factors. Evidence suggests that lipoic acid supplementation can improve endothelial function by increasing nitric oxide availability and reducing markers of oxidative stress. Some small human trials have demonstrated modest improvements in flow-mediated dilation (an indicator of arterial health) and reductions in biomarkers like C-reactive protein and LDL oxidation. Additionally, ALA has been shown to improve insulin sensitivity and reduce blood pressure, both of which are beneficial for arterial health.

However, the quality and scale of clinical evidence remain moderate. Most studies are small, short-term, or involve patients with diabetes or metabolic syndrome rather than the general population. While the mechanistic rationale is strong and there is some clinical support, larger, long-term trials are required to confirm whether lipoic acid supplementation provides significant and consistent benefits for arterial health in diverse populations. Nonetheless, current evidence provides a reasonable scientific basis for the use of lipoic acid to support arterial function, albeit with some limitations regarding the strength of the data.

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Products containing Lipoic Acid

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