Evidence supporting the use of: Procyanidin
For the body system: Arteries
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Procyanidins are a class of polyphenolic compounds found in various plants, particularly in grape seeds, cocoa, apples, and pine bark. Their use to support the arteries and overall cardiovascular health is backed by a moderate amount of scientific evidence, primarily from in vitro studies, animal models, and a growing number of human clinical trials. Procyanidins exhibit strong antioxidant properties, which help protect endothelial cells (the cells lining the arteries) from oxidative stress—a key contributor to atherosclerosis and arterial dysfunction. Additionally, some studies have shown that procyanidins can improve endothelial function by enhancing nitric oxide production, which relaxes blood vessels and supports healthy blood flow. Meta-analyses and clinical trials, especially those using grape seed extract (a rich source of procyanidins), have reported modest reductions in blood pressure and improvements in vascular elasticity. However, results are not entirely consistent, and the quality of evidence varies depending on the preparation and dosage used. The European Food Safety Authority (EFSA) has not authorized health claims for procyanidins specifically for arterial health due to insufficient conclusive evidence, but research remains ongoing. Overall, while there is no strong consensus or regulatory endorsement, the use of procyanidins to support arterial health is justified by a moderate level of scientific validation—mainly based on their antioxidant and vasodilatory effects.
Other ingredients that support Arteries
Adrenergic aminesAescin
Ajoene
Algae
algal oil
Allicin
Alliin
Allium tuberosum
Almond fruit
Alpha phytosterol
alpha-linolenic acid (ALA)
alpha-lipoic acid
amaranth
amino acids
anchovies
anthocyanidins
anthocyanins
anthocyanosides
apocynin
apple
arginine alpha ketoglutarate
Arginine aspartate
Arginine malate
Arginine nitrate
Arginine silicate
arjun tree
arjuna
arjunic acid
Arjunolic acid
Aronia melanocarpa
artichoke
asiaticoside
astaxanthin
Auricularia
avocado
Baccharis dracunculifolia
baicalein
baicalin
Baikal Skullcap
barley
beet
Berberis (unspecified)
bergamot
berry
betanin
Bidens pilosa
bignay
bilberry
bioflavonoids
bishop\'s weed
black cumin
black currant
black garlic
black ginger
black seed
black tea
blackberry
blueberry
bok choy
bonito peptide
bran
Brassica
broccoli
Brown Algae
Brussel sprouts
brutieridin
Buckwheat
butcher's broom
butylphthalide
calamari oil
Calanus finmarchicus
camelina oil
Camellia sinensis
campesterol
capsaicin
capsaicinoids
capsicum
capsinoids
carnosol
Carthamus
Casearia sylvestris
catechins
catecholamine
cayenne pepper
celery
cherry
chestnut
chia seed
chia seed
Chinese salvia root
chlorogenic acid
chocolate
chokeberry
Cinnamomum
cinnamon
Citrus
citrus bioflavonoids
citrus pectin
citrus sinensis (proprietary)
cocoa
cod liver oil
coenzyme Q10 (CoQ10)
Collinsonia
commiphora
crocetin
cruciferous
Curcuma
curcumin
Curcuminoid
cyanidin
Cyathula
cypress
d-alpha tocopherol
danshen
delphinidin
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
diallyl sulfide
diallyl trisulfide (DATS)
diosmetin
Diosmin
docosahexaenoic Acid
DPA (docosapentaenoic acid)
dulse
egg
eicosapentaenoic acid
elastin
electrolytes blend (proprietary)
ellagic acid
ellagitannin
emblicanin
EPA (eicosapentaenoic acid)
epicatechin
epigallocatechin gallate (EGCG)
eriocitrin
escin
eucommia
Eucommia ulmoides
Evodia
Fagopyrum
fat liver oil
fatty acids
ferulic acid
fiber blend (proprietary)
fibroblast growth factor
fish
fish oil
fish protein
flavanols
flavanones
flavans
flavoglycosides
flavones
flavonoids
flavonols
flavonones
flaxseed
foxglove
fructoborate
fruit
fruit and vegetable blend (proprietary)
fruit blend (proprietary)
gamma tocopherol
ganoderma
garlic
garlic bulb
ginger
ginkgo biloba
ginkgo flavone glycoside
ginkgolides
Ginkgoside
ginseng
Ginsenosides
Glucoraphanin
gooseberry
gotu kola
grape
green tea
guggul
Gypenoside
Haematococcus pluvialis
hawthorn
hawthorn
hazelnut
herbal blend (proprietary)
hesperetin
hesperidin
hibiscus
honey
horse chestnut
hydroxycinnamic acid
hydroxyphenylethanols
hydroxytyrosol
Indian frankincense
inula racemosa
isothiocyanates
jiaogulan
Kaempferol
kale
Khella
knotweed
krill oil
kuding tea
L-arginine
L-citrulline
Lactotripeptides
Large-leaved linden
lemon
Lentil
lignans
Ligusticum
Ligustrazin
linden
lingzhi
linoleic acid (LA)
linseed oil
lipids
Loranthus
lumbrokinase
lycopene
magnesium
malvidin
mangiferin
Marine fat
Marine lipid
Marjoram
Matcha
Methylxanthine
Mineral ascorbate
Monacolin
Monoterpenes
Monounsaturated fat
Moringa
Morus
Motherwort
Mulberry
mustard seed
Naringenin
Naringin
Nattokinase
Niacin (vitamin B3)
Niacinamide (vitamin B3)
Nigella seed
Nobiletin
noni
oleic acid
Oleoperin
Oleuropein
Oligomeric proanthocyanidins
olive
omega-3 fatty acids
omega-6 fatty acids
omega-7 fatty acids
omega-9 fatty acids
onion
oolong tea
orange
pagoda tree
palmitoleic acid
Pecan
Pentacyclic triterpenoids
phenolic compounds
Phenylpropanoids
Phthalides
phytosterols
pine bark
Pinolenic acid
Pistachio
plant sterols
Plukenetia volubilis
Polydatin
polymethoxylated flavones
polyphenols
polyunsaturated fat
pomegranate
potassium
prickly ash
proanthocyanidins
procyanidin
procyanidol
Propionyl-L-Carnitine
pu-er tea
Puerarin
pumpkin
punicalagins
purple tea
purslane
Pycnogenol
quercetin
rapeseed oil
Rauvolfia
red yeast
red yeast rice
resveratrol
Rhus coraria
Rhus coriaria
Rosa roxburghii
rose hips
rosemary
Ruscogenins
Ruscus
rutin
Rutosides
S-allylcysteine
Sacha Inchi
safflower oil
Salmon Oil
Salvianolic acid
Schizochytrium
Schizochytrium Oil
Scotch Broom
seaweed
Serrapeptase
sesame
Sesamin
shepherd's purse
Sichuan Lovage
sitostanol
Sitosterol
Soy
soybean
spinach
sterols
Stigmastanol
Stilbenoid
Stone Root
strawberry
Sulfated polysaccharide
Sulforaphane
Sunflower oil
Sweet Clover
Szechuan lovage
Tamarind
Tanshinone
Taurine
Taxifolin
Tea
Tejocote
Terminalia
terpene lactones
Terpenoids
Theaflavin
Theobromine
Thiosulfinate
Thymoquinone
tocotrienols
trace minerals
Trans-pterostilbene
Triterpenes
Tropical jewel hisbiscus
Troxerutin
turmeric
Tyrosol
ubiquinol
vegetable and fruit blend (proprietary)
vitamin B
vitamin C
vitamin D
vitamin E
vitamin K
Vitexin
Wakame
Walnut
Watercress
Watermelon
White Tea
Xanthohumol
Xantinol Nicotinate
Yarrow
Yerba mate
Zinc
Other body systems supported by procyanidin
ArteriesBlood
Brain
Capillaries
Circulatory System
Gums
Heart
Immune System
Skin
Veins