Evidence supporting the use of: Serrapeptase
For the body system: Arteries
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Serrapeptase is a proteolytic enzyme originally isolated from bacteria in the digestive tract of silkworms. It is marketed as a supplement with purported benefits for cardiovascular health, including supporting arterial health by reducing inflammation and helping to break down atherosclerotic plaques. Some preliminary scientific studies and small clinical trials suggest serrapeptase may reduce inflammation and promote the breakdown of fibrin and other protein-based byproducts involved in arterial plaque formation. However, the total body of evidence is limited, often of low quality, and many studies have methodological weaknesses such as small sample sizes, lack of controls, or short durations.
There are no large-scale, high-quality randomized controlled trials confirming that serrapeptase directly benefits arterial health or prevents/treats atherosclerosis in humans. Most of the available evidence comes from in vitro studies, animal models, or pilot clinical trials focusing on its anti-inflammatory and fibrinolytic properties. While the biological plausibility for cardiovascular benefit exists, robust clinical validation is lacking. Major medical organizations do not currently recommend serrapeptase for arterial or cardiovascular health due to insufficient evidence. In summary, while there is some scientific investigation into the use of serrapeptase for arterial support, the evidence remains weak, and its use is not widely accepted in mainstream medicine.
Other ingredients that support Arteries
ajoenealgal oil
alpha-linolenic acid (ALA)
amino acids
anchovies
anthocyanins
apple
arjun tree
artichoke
astaxanthin
barley
beet
bergamot
bilberry
black cumin
black currant
black garlic
sesame
black tea
blackberry
blueberry
bonito peptide
Indian frankincense
broccoli
brussel sprouts
butcher's broom
calamari oil
campesterol
canola oil
capsaicinoids
catechins
celery
cherry
chia seed
Chinese salvia root
chokeberry
cinnamon
citrus bioflavonoids
citrus pectin
citrus sinensis (proprietary)
coenzyme Q10 (CoQ10)
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ethanol
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
fruit and vegetable blend (proprietary)
fruit blend (proprietary)
gamma tocopherol
garlic bulb
ginger
ginkgo biloba
ginseng
gooseberry
gotu kola
grape
onion
green tea
guggul
hawthorn
hawthorn
hesperetin
hesperidin
hibiscus
horse chestnut
knotweed
kale
krill oil
l-arginine
l-citrulline
lemon
lignans
linoleic acid (LA)
lycopene
mackerel
magnesium
marine lipid
matcha
moringa
motherwort
mustard seed
naringin
nattokinase
niacin (vitamin B3)
niacinamide (vitamin B3)
oleic acid
olive
omega-3 fatty acids
omega-6 fatty acids
omega-7 fatty acids
omega-9 fatty acids
orange
palmitoleic acid
phenolic acids
phytosterols
pine bark
plant sterols
pomegranate
potassium
pumpkin
quercetin
red yeast rice
resveratrol
rose hips
rosemary
rutin
safflower oil
sardines
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sitostanol
soybean
spinach
sterols
strawberry
tocotrienols
tomato
trans-pterostilbene
almond fruit
ubiquinol
vegetable and fruit blend (proprietary)
vitamin B
vitamin C
vitamin D
vitamin E
vitamin K
seaweed
water
watercress
watermelon
mulberry
zinc
jiaogulan
capsicum
inula racemosa
commiphora
lingzhi
lingusticum wallichii
yarrow
prickly ash
morus
sodium salt
ferulic acid
eucommia
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terpene lactones
polyphenols
trace minerals
purslane
shepherd's purse
yerba mate
noni
amaranth
herbal blend (proprietary)
algae
cocoa
cayenne pepper
Arjuna
Arginine Alpha Ketoglutarate
Arginine nitrate
Asiaticoside
Aronia melanocarpa
Allicin
Arginine malate
Arginine aspartate
Auricularia
Avocado
Adrenergic amines
Alpha-Lipoic Acid
Adrenaline
Aescin
anthocyanidins
Alpha phytosterol
Acetylsalicylic acid
Arjunic Acid
Alliin
anthocyanosides
Allium tuberosum
Apocynin
Arginine silicate
Arjunolic acid
Black Seed
Butylphthalide
Baikal Skullcap
Bidens pilosa
Brutieridin
Brown Algae
Brassica
Bishop's Weed
Bran
Baccharis dracunculifolia
Berberis (unspecified)
Bok Choy
Baicalein
Betanin
berry
Bioflavonoids
Baicalin
Buckwheat
Bignay
Chia seed
Camellia sinensis
Cinnamomum
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Camelina Oil
Cod Liver Oil
Cyathula
Cyanidin
chlorogenic acid
Curcuminoid
Citrus
Capsaicin
Catecholamine
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Chocolate
Curcuma
Carnosol
Calanus finmarchicus
cypress
Chestnut
Crocetin
Collinsonia
Carthamus
Casearia sylvestris
Docosahexaenoic Acid
Diallyl sulfide
Diosmin
Danshen
Delphinidin
Dulse
Diosmetin
epicatechin
Ellagic Acid
Eriocitrin
Egg
Emblicanin
Eicosapentaenoic Acid
Escin
Eucommia ulmoides
Elastin
Ellagitannin
Flavonoids
Flavonones
fibroblast growth factor
Garlic
Pistachio
walnut
Other body systems supported by Serrapeptase
ArteriesBlood
Bronchials
Circulatory System
Lungs
Mucus Membranes
Sinuses