Evidence supporting the use of: Vitamin B9
For the body system: Arteries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B9, also known as folic acid or folate, has scientific validation for its role in supporting arterial and overall cardiovascular health. The primary mechanism involves its ability to lower homocysteine levels in the blood. Elevated homocysteine is a known risk factor for atherosclerosis (hardening and narrowing of the arteries) and other cardiovascular diseases. Folate acts as a cofactor in the conversion of homocysteine to methionine, thereby reducing circulating homocysteine concentrations. Several observational studies and randomized controlled trials have shown that folic acid supplementation can effectively reduce homocysteine levels. However, evidence linking folic acid supplementation directly to reduced cardiovascular events (such as heart attack or stroke) is mixed, with some large trials showing modest benefit and others showing little or no effect. The American Heart Association does not currently recommend routine use of folic acid supplements for cardiovascular disease prevention in the general population, but supplementation is considered beneficial in certain groups, such as individuals with elevated homocysteine or folate deficiency. Overall, the evidence supports a biological rationale and some clinical benefit for arterial health, though the impact on clinical outcomes is not robust enough for universal recommendation.

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Products containing Vitamin B9

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