Evidence supporting the use of: Alpha-Linolenic Acid
For the health condition: Arteriosclerosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-Linolenic Acid (ALA) is an omega-3 fatty acid found primarily in plant oils, such as flaxseed, chia, and walnuts. There is some scientific evidence suggesting that ALA may have a beneficial effect on cardiovascular health, including conditions related to arteriosclerosis (the thickening or hardening of the arteries). Epidemiological studies have observed that higher dietary intake of ALA is associated with a modest reduction in the risk of cardiovascular disease. Proposed mechanisms include the anti-inflammatory effects of ALA, its ability to reduce blood lipid levels (such as triglycerides), and its potential to improve endothelial function.

However, the direct evidence supporting ALA supplementation specifically for the treatment or prevention of arteriosclerosis is limited and less robust than that for long-chain omega-3 fatty acids (EPA and DHA) from marine sources. Most clinical trials involving ALA show only modest or equivocal benefits. Systematic reviews and meta-analyses suggest a possible, but not definitive, reduction in cardiovascular events with increased ALA intake. Therefore, while there is some scientific rationale and early evidence for ALA's role in supporting arterial health, more high-quality, targeted studies are needed to firmly establish its efficacy in arteriosclerosis.

In summary, ALA is used based on scientific rationale with moderate but not strong clinical evidence for its benefit in arteriosclerosis, warranting a rating of 2 out of 5 for evidence strength.

More about Alpha-Linolenic Acid
More about Arteriosclerosis

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