Evidence supporting the use of: Alpha-linolenic acid (ALA)
For the health condition: Arteriosclerosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-linolenic acid (ALA) is a plant-derived omega-3 fatty acid found in foods such as flaxseed, chia seeds, walnuts, and canola oil. The rationale for its use in supporting or treating arteriosclerosis (the thickening and hardening of arterial walls) is grounded in its anti-inflammatory and lipid-lowering properties, which have been linked to cardiovascular health. Several epidemiological studies have shown that higher dietary intake of ALA is associated with a reduced risk of cardiovascular diseases, which are frequently related to arteriosclerosis. Some intervention trials have demonstrated modest improvements in blood lipid profiles and endothelial function with increased ALA intake. For example, a 2012 meta-analysis (Pan et al., Am J Clin Nutr) found an inverse association between ALA consumption and cardiovascular disease risk.

However, evidence specifically targeting arteriosclerosis is limited. Most clinical trials have small sample sizes and short durations, and results regarding ALA's direct effect on arterial plaque progression or regression are inconsistent. The conversion rate of ALA to the more bioactive long-chain omega-3s (EPA and DHA) is also quite low in humans, which may limit its efficacy compared to marine-derived omega-3s.

In summary, while there is some scientific rationale and preliminary evidence for ALA’s beneficial effects on cardiovascular health, the strength of evidence specifically for arteriosclerosis is modest. The use of ALA is therefore supported by scientific evidence, but the quality and directness of this evidence warrant a rating of 2 out of 5.

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