Evidence supporting the use of: Curcumin
For the health condition: Arteriosclerosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Curcumin, the active compound in turmeric (Curcuma longa), has been studied for its potential benefits in a variety of cardiovascular conditions, including arteriosclerosis (the thickening and hardening of arterial walls). Several preclinical studies and a limited number of human clinical trials suggest curcumin may exert protective effects against arteriosclerosis through multiple mechanisms. These include its anti-inflammatory and antioxidant properties, inhibition of vascular smooth muscle cell proliferation, and reduction of lipid accumulation within the arterial wall. Curcumin has also been shown to downregulate the expression of adhesion molecules and cytokines involved in the development of atherosclerotic plaques.

A 2017 meta-analysis of randomized controlled trials found some evidence that curcumin supplementation can improve markers related to endothelial function and lipid profiles, both of which are relevant to arteriosclerosis risk. However, most of the available studies are small, short-term, and often use surrogate endpoints rather than direct measures of arterial stiffness or plaque progression. Additionally, curcumin’s bioavailability in humans is low, which could limit its effectiveness unless specialized formulations are used.

In summary, while there is a scientific rationale and some promising preliminary evidence supporting the use of curcumin for arteriosclerosis, high-quality, large-scale clinical trials are lacking. The current evidence base is suggestive but not definitive, justifying a moderate-low evidence rating.

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