Evidence supporting the use of: D-alpha tocopherol
For the health condition: Arteriosclerosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

D-alpha tocopherol, the natural form of vitamin E, has been investigated for its potential role in supporting or treating arteriosclerosis, a condition characterized by the thickening and hardening of arterial walls. The scientific rationale primarily relates to vitamin E’s function as an antioxidant. It has been proposed that oxidative modification of low-density lipoprotein (LDL) cholesterol is a key event in the development of atherosclerosis, a major component of arteriosclerosis. Vitamin E, as a lipid-soluble antioxidant, may help inhibit LDL oxidation and thus slow the progression of arterial damage.

However, while early observational studies suggested that higher intakes of vitamin E were associated with reduced cardiovascular risk, large randomized controlled trials (RCTs) have not consistently demonstrated significant benefit. For example, the HOPE and Heart Protection Study trials found no significant reduction in cardiovascular events with vitamin E supplementation. Some meta-analyses have even raised concerns about potential harms at high dosages. Thus, current major guidelines do not recommend vitamin E supplementation specifically for the prevention or treatment of arteriosclerosis.

In summary, while there is a scientific rationale and some preliminary evidence for the use of d-alpha tocopherol in arteriosclerosis, robust clinical trial data do not support its effectiveness for this purpose, resulting in a modest evidence rating.

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