Dietary fiber, often provided as a "fiber blend" in proprietary products, is scientifically validated for cardiovascular health, including the management and prevention of arteriosclerosis (the thickening and hardening of arterial walls). Multiple large-scale epidemiological studies and randomized controlled trials have shown that increased intake of dietary fiber—particularly soluble fiber—can reduce total and LDL cholesterol levels, which are major risk factors for arteriosclerosis. The mechanism involves fiber's ability to bind bile acids in the intestine, promoting their excretion and thereby reducing cholesterol absorption. Additionally, fiber can improve glycemic control and reduce systemic inflammation, both of which are relevant to arteriosclerosis pathology.

The American Heart Association and similar organizations recommend higher dietary fiber intake as part of a heart-healthy diet. While there is strong evidence supporting fiber-rich diets (such as those high in fruits, vegetables, legumes, and whole grains), the evidence for specific proprietary “fiber blends” is somewhat less robust, as the effects may depend on the types and ratios of fibers included. Nonetheless, the general consensus is that fiber supplementation is a valid adjunct in the dietary management of arteriosclerosis risk, primarily due to its cholesterol-lowering effects and other beneficial impacts on vascular health.

However, fiber blends should be seen as part of a comprehensive lifestyle approach, rather than a sole solution. The evidence score of 3 reflects solid support from dietary fiber research, but less direct clinical evidence for proprietary blends specifically formulated for arteriosclerosis.