Evidence supporting the use of: Flavonoids
For the health condition: Arteriosclerosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavonoids are a diverse group of plant-derived polyphenolic compounds found abundantly in fruits, vegetables, tea, and wine. There is a growing body of scientific evidence suggesting that flavonoids may help in the prevention and management of arteriosclerosis (also known as atherosclerosis), primarily due to their antioxidant, anti-inflammatory, and vasoprotective properties. Epidemiological studies have observed that higher dietary intake of flavonoid-rich foods is associated with a reduced risk of cardiovascular diseases, including arteriosclerosis. Experimental studies indicate that flavonoids can inhibit the oxidation of low-density lipoprotein (LDL) cholesterol, reduce endothelial dysfunction, and modulate inflammatory responses—all key processes in the development of arteriosclerotic plaques.

However, most evidence comes from observational studies and animal models; direct intervention trials in humans using isolated flavonoids are limited and results are sometimes inconsistent. Meta-analyses have shown modest but significant associations between higher flavonoid intake and improved markers of vascular health, but causality has not been firmly established. Therefore, while scientific evidence supports a potential benefit of flavonoids in reducing the risk or progression of arteriosclerosis, more high-quality randomized clinical trials are needed to confirm these effects and determine effective dosages.

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