Evidence supporting the use of: Hesperidin
For the health condition: Arteriosclerosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hesperidin is a flavonoid primarily found in citrus fruits and is sometimes used as a dietary supplement for cardiovascular health, including conditions like arteriosclerosis (the thickening and hardening of arterial walls). The rationale for its use is based on its antioxidant, anti-inflammatory, and vasoprotective properties observed in preclinical studies. Animal and in vitro research suggest hesperidin may reduce oxidative stress and inflammation, both of which are contributors to the development of arteriosclerosis. Some studies have shown hesperidin can improve endothelial function, reduce blood pressure, and inhibit the formation of atherosclerotic plaques in animal models.

However, robust clinical evidence in humans is limited. A handful of small clinical studies have investigated hesperidin’s effects on blood pressure, cholesterol, and markers of vascular health, with mixed results. A 2015 randomized controlled trial found that orange juice rich in hesperidin improved endothelial function in healthy men. Other studies have demonstrated modest improvements in lipid profiles and reductions in markers of inflammation. Despite these findings, there are few, if any, large-scale clinical trials specifically evaluating hesperidin’s impact on arteriosclerosis progression or clinical outcomes in humans.

In summary, while preclinical data and some early human studies suggest potential benefits of hesperidin for vascular health, the evidence supporting its use specifically for arteriosclerosis remains preliminary. More high-quality clinical trials are required to establish its efficacy and safety for this indication.

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