Evidence supporting the use of: Oligomeric proanthocyanidins
For the health condition: Arteriosclerosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Oligomeric proanthocyanidins (OPCs), commonly extracted from grape seeds, pine bark, and other plant sources, have been studied for their vascular-protective properties, including potential benefits in arteriosclerosis (atherosclerosis). The scientific rationale for their use centers on their potent antioxidant activity, ability to inhibit LDL oxidation, and reported effects on endothelial function. Several in vitro and animal studies suggest that OPCs can protect vascular endothelium from oxidative stress and reduce inflammation, both of which are key contributors to the development of arteriosclerosis. Additionally, some small human trials and meta-analyses indicate that OPC supplementation may modestly improve markers of vascular health, such as blood pressure and endothelial function. However, the evidence is limited by small sample sizes, short durations, and variability in OPC formulations. There is currently insufficient large-scale, high-quality clinical trial data to conclusively establish OPCs as an effective treatment or preventive agent for arteriosclerosis. Thus, while the use of OPCs for this condition is scientifically motivated and supported by preliminary studies, the overall strength of the evidence is low to moderate, justifying a rating of 2 out of 5.

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