Evidence supporting the use of: Resveratrol
For the health condition: Arteriosclerosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol is a polyphenolic compound most notably found in the skin of red grapes, and has been studied for its potential cardiovascular benefits, including in the context of arteriosclerosis (the thickening and hardening of arterial walls). The scientific rationale for using resveratrol primarily stems from its antioxidant, anti-inflammatory, and vasoprotective properties, which have been demonstrated in various in vitro and animal studies. Resveratrol appears to reduce oxidative stress, inhibit LDL cholesterol oxidation, and improve endothelial function, all of which are mechanisms involved in the progression of arteriosclerosis.

However, while these mechanisms provide a plausible basis for its benefit, the clinical evidence in humans remains limited and inconclusive. A few small-scale human trials and meta-analyses have suggested that resveratrol supplementation may modestly improve some markers of cardiovascular health, such as arterial stiffness and endothelial function. Despite this, there is a lack of large, well-controlled clinical trials specifically addressing its impact on the progression or treatment of arteriosclerosis. Furthermore, issues related to bioavailability and effective dosing in humans remain unresolved.

In summary, the use of resveratrol for arteriosclerosis is scientifically motivated and supported by preclinical and some early clinical data, but the overall quality and quantity of clinical evidence is currently low to moderate, warranting a rating of 2/5 for evidence strength.

More about resveratrol
More about Arteriosclerosis

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