Sesamin is a lignan compound found in sesame seeds and oil. Its use for supporting or treating arteriosclerosis (the thickening and hardening of artery walls) is primarily based on emerging scientific evidence from preclinical and some limited clinical studies, rather than on traditional medicine. Research has shown that sesamin possesses antioxidant, anti-inflammatory, and lipid-lowering properties, all of which are relevant to the prevention and progression of arteriosclerosis.

Animal studies have demonstrated that sesamin supplementation can reduce serum cholesterol, triglyceride levels, and inhibit the development of atherosclerotic lesions. It appears to modulate lipid metabolism by downregulating genes involved in cholesterol synthesis and upregulating those responsible for lipid clearance. Additionally, sesamin has shown potential to reduce oxidative stress and inflammation in vascular tissue, both of which are key processes in arteriosclerosis.

However, the evidence in humans is still limited. A few small clinical trials and observational studies suggest potential cardiovascular benefits, such as improved lipid profiles, but there is insufficient high-quality evidence to confirm sesamin's efficacy in treating or preventing arteriosclerosis in humans. Thus, while sesamin has a scientific rationale and promising preclinical data, more robust clinical trials are needed for definitive conclusions.