Evidence supporting the use of: Unsaturated Fat
For the health condition: Arteriosclerosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Unsaturated fats, especially polyunsaturated and monounsaturated fats, have strong scientific support for their role in the prevention and management of arteriosclerosis (atherosclerosis). Clinical and epidemiological studies have shown that replacing saturated fats with unsaturated fats in the diet can significantly reduce blood levels of low-density lipoprotein (LDL) cholesterol, a primary risk factor for arteriosclerosis. For instance, multiple large-scale trials, such as the PREDIMED study and the Seven Countries Study, have demonstrated that diets rich in unsaturated fats (like the Mediterranean diet, which emphasizes olive oil and nuts) are associated with lower rates of cardiovascular disease, including arteriosclerosis. The mechanism involves unsaturated fats improving lipid profiles by lowering LDL cholesterol and sometimes raising high-density lipoprotein (HDL) cholesterol. Additionally, unsaturated fats can reduce inflammation and improve endothelial function, both of which are important in slowing the progression of arterial plaque buildup. The American Heart Association and other major health organizations recommend replacing saturated fats with unsaturated fats as a key dietary strategy to reduce the risk of arteriosclerosis and related cardiovascular diseases. While not a direct "treatment," regular consumption of unsaturated fats as part of a balanced diet is a well-validated approach to support cardiovascular health and prevent arteriosclerotic changes.

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